Diet-microbe co-metabolic interactions in wild primates reveal clues on human evolution

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F15%3A43873369" target="_blank" >RIV/62157124:16170/15:43873369 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Diet-microbe co-metabolic interactions in wild primates reveal clues on human evolution

Popis výsledku v původním jazyce

Recent advances in microbiome studies and meta-"OMICS" have offered new molecular insights into how host-microbe systems impact mammalian physiology. Here, we test the hypothesis that the molecular characterization of diet - gut microbe interactions in wild primates also provides valuable information on the factors that triggered human evolution. Thus, we use a longitudinal approach, along with high throughput sequencing and metabolomics to characterize the gut microbiome and metabolomes in 356 fecal samples of Cercocebus agilis, Gorilla beringei, Gorilla gorilla, Pan troglodites schweinfurthii and Homo sapiens. Our results show that the diet-microbe co-metabolic landscape of wild primates converges with that of humans when foraging is focused on increased energy harvest; specifically, as far as predominance of microbes and metabolites involved in simple sugar processing and lipid turnover. As such, we present evidence that primitive dietary shifts to foods with high contents of readil

Název v anglickém jazyce

Diet-microbe co-metabolic interactions in wild primates reveal clues on human evolution

Popis výsledku anglicky

Recent advances in microbiome studies and meta-"OMICS" have offered new molecular insights into how host-microbe systems impact mammalian physiology. Here, we test the hypothesis that the molecular characterization of diet - gut microbe interactions in wild primates also provides valuable information on the factors that triggered human evolution. Thus, we use a longitudinal approach, along with high throughput sequencing and metabolomics to characterize the gut microbiome and metabolomes in 356 fecal samples of Cercocebus agilis, Gorilla beringei, Gorilla gorilla, Pan troglodites schweinfurthii and Homo sapiens. Our results show that the diet-microbe co-metabolic landscape of wild primates converges with that of humans when foraging is focused on increased energy harvest; specifically, as far as predominance of microbes and metabolites involved in simple sugar processing and lipid turnover. As such, we present evidence that primitive dietary shifts to foods with high contents of readil

Druh

O - Ostatní výsledky

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

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Projekt

<a href="/cs/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: CEITEC - central european institute of technology</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů