Urinary biomarkers of renal function in dogs and cats

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Urinary biomarkers of renal function in dogs and cats

Popis výsledku v původním jazyce

Kidney diseases commonly affect dogs and cats. Early diagnosis of renal impairment may be challenging even with urinalysis providing additional information. Serum creatinine concentration is often used in the diagnosis, but it is a relatively insensitivemarker of renal function. Particular attention is aimed at the investigation of certain molecules that may occur in urine at elevated levels as a result of glomerular or tubular dysfunction. These changes may be found before the increase of serum creatinine levels. This review article summarizes reports of urine biomarkers and their ability to detect early kidney disease in dogs and cats. Implementation of multiple urinary biomarkers in diagnosis of acute kidney injury and chronic kidney disease may increase its specificity and sensitivity. Early diagnosis of reduced renal functional mass allows early therapeutic interventions which may decrease morbidity and mortality.

Název v anglickém jazyce

Urinary biomarkers of renal function in dogs and cats

Popis výsledku anglicky

Kidney diseases commonly affect dogs and cats. Early diagnosis of renal impairment may be challenging even with urinalysis providing additional information. Serum creatinine concentration is often used in the diagnosis, but it is a relatively insensitivemarker of renal function. Particular attention is aimed at the investigation of certain molecules that may occur in urine at elevated levels as a result of glomerular or tubular dysfunction. These changes may be found before the increase of serum creatinine levels. This review article summarizes reports of urine biomarkers and their ability to detect early kidney disease in dogs and cats. Implementation of multiple urinary biomarkers in diagnosis of acute kidney injury and chronic kidney disease may increase its specificity and sensitivity. Early diagnosis of reduced renal functional mass allows early therapeutic interventions which may decrease morbidity and mortality.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Veterinární medicína

ISSN

0375-8427

e-ISSN

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Svazek periodika

60

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

14

Strana od-do

589-602

Kód UT WoS článku

000365086800001

EID výsledku v databázi Scopus

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