Prevalence and prognostic value of c-kit and TP53 mutations in canine mast cell tumours

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F19%3A43877292" target="_blank" >RIV/62157124:16170/19:43877292 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00027162:_____/19:N0000002

Výsledek na webu

<a href="https://doi.org/10.1016/j.tvjl.2019.03.005" target="_blank" >https://doi.org/10.1016/j.tvjl.2019.03.005</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.tvjl.2019.03.005" target="_blank" >10.1016/j.tvjl.2019.03.005</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Prevalence and prognostic value of c-kit and TP53 mutations in canine mast cell tumours

Popis výsledku v původním jazyce

Cutaneous mast cell tumours (MCI&apos;) are among the most frequent malignancies in dogs. Their clinical behaviour is highly variable and, with the exception of mutations in the c-kit gene, little is known about their genetic aetiology. The mutational status of the c-kit exons 8, 9 and 11, and exons 5-8 of the TP53 gene was analysed to find markers for molecular stratification of MCTs and predictors of clinical outcome. Mutations in the c-kit gene were detected in 19.5% (n = 8/41) samples and their presence was significantly associated with the high histopathologica I grade (P=0.038). Mutations in the DNA binding domain of the TP53 gene were found in 14.6% (n = 6/41) of the analysed MCTs, and their frequency was similar in low and high grade MCTs (P&gt;0.05). TP53 mutations were not useful prognostic factors in this sample of canine cutaneous MCTs.

Název v anglickém jazyce

Prevalence and prognostic value of c-kit and TP53 mutations in canine mast cell tumours

Popis výsledku anglicky

Cutaneous mast cell tumours (MCI&apos;) are among the most frequent malignancies in dogs. Their clinical behaviour is highly variable and, with the exception of mutations in the c-kit gene, little is known about their genetic aetiology. The mutational status of the c-kit exons 8, 9 and 11, and exons 5-8 of the TP53 gene was analysed to find markers for molecular stratification of MCTs and predictors of clinical outcome. Mutations in the c-kit gene were detected in 19.5% (n = 8/41) samples and their presence was significantly associated with the high histopathologica I grade (P=0.038). Mutations in the DNA binding domain of the TP53 gene were found in 14.6% (n = 6/41) of the analysed MCTs, and their frequency was similar in low and high grade MCTs (P&gt;0.05). TP53 mutations were not useful prognostic factors in this sample of canine cutaneous MCTs.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

40301 - Veterinary science

Projekt

<a href="/cs/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Veterinary Journal

ISSN

1090-0233

e-ISSN

—

Svazek periodika

247

Číslo periodika v rámci svazku

MAY

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

4

Strana od-do

71-74

Kód UT WoS článku

000466622700011

EID výsledku v databázi Scopus

2-s2.0-85063340168