The borrelial myocarditis in dog - 1st case report

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The borrelial myocarditis in dog - 1st case report

Popis výsledku v původním jazyce

Borreliosis is a well-known condition that can induce several clinical syndromes in human beings and animals leading to several complications even death. The less common myocardial form of the disease can lead to arrhythmia and myocardial inflammation; those changes may induce cardiomyopathy, which is a serious manifestation of the disease though rare. This presentation describes a case of an 8-year-old female Labrador retriever that was admitted due to progressive movement complications (reluctance to move, fatigue), neuromuscular signs (generalized body weakness, decreased flexor reflexes, dysphonia) and polypnea and irregular heart rhythm. The female was often infested by ticks. During hospitalization the patient developed different types of arrhythmias (supraventricular tachycardia, several degrees of atrioventricular blocks and ventricular bigeminism) that did not respond well to therapy (infusion therapy, doxycycline, antiarrhythmics, furosemide). There was seropositivity to Borrelia sp. (positive Borrelia-C6 SNAP 4Dx Plus test and borrelia indirect fluorescent antibody IgM and IgG tests confirmed with Western blott with positive VlsE and OpsC bands). Negative ELISA IgG OspA confirmed that animal was not vaccinated against Borrelia sp. Serum was also positive for Toxoplasma gondii IgM and IgG antibodies. Increased cardiac troponins and NT-proBNP showed severe myocardial damage and ongoing cardiac failure. The dog subsequently died as a result of heart disease and arrest after ventricular fibrillation. Pathology demonstrated myocarditis. Real-time PCR of myocardium confirmed positivity to borreliosis. Positive sample was sequenced as B. burgdorferi sensu stricto. DNA T. gondii was not detected in heart tissue samples by real-time PCR. The correlation of serology, cardiac markers, clinical course, pathology concluded a Lyme myocarditis. The myocardial damage caused by T. gondii was excluded negative PCR. To the authors? knowledge this would be the first confirmed case of borreliosis inducing myocarditis and sudden death in a dog.

Název v anglickém jazyce

The borrelial myocarditis in dog - 1st case report

Popis výsledku anglicky

Borreliosis is a well-known condition that can induce several clinical syndromes in human beings and animals leading to several complications even death. The less common myocardial form of the disease can lead to arrhythmia and myocardial inflammation; those changes may induce cardiomyopathy, which is a serious manifestation of the disease though rare. This presentation describes a case of an 8-year-old female Labrador retriever that was admitted due to progressive movement complications (reluctance to move, fatigue), neuromuscular signs (generalized body weakness, decreased flexor reflexes, dysphonia) and polypnea and irregular heart rhythm. The female was often infested by ticks. During hospitalization the patient developed different types of arrhythmias (supraventricular tachycardia, several degrees of atrioventricular blocks and ventricular bigeminism) that did not respond well to therapy (infusion therapy, doxycycline, antiarrhythmics, furosemide). There was seropositivity to Borrelia sp. (positive Borrelia-C6 SNAP 4Dx Plus test and borrelia indirect fluorescent antibody IgM and IgG tests confirmed with Western blott with positive VlsE and OpsC bands). Negative ELISA IgG OspA confirmed that animal was not vaccinated against Borrelia sp. Serum was also positive for Toxoplasma gondii IgM and IgG antibodies. Increased cardiac troponins and NT-proBNP showed severe myocardial damage and ongoing cardiac failure. The dog subsequently died as a result of heart disease and arrest after ventricular fibrillation. Pathology demonstrated myocarditis. Real-time PCR of myocardium confirmed positivity to borreliosis. Positive sample was sequenced as B. burgdorferi sensu stricto. DNA T. gondii was not detected in heart tissue samples by real-time PCR. The correlation of serology, cardiac markers, clinical course, pathology concluded a Lyme myocarditis. The myocardial damage caused by T. gondii was excluded negative PCR. To the authors? knowledge this would be the first confirmed case of borreliosis inducing myocarditis and sudden death in a dog.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

40301 - Veterinary science

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů