Edible dormice (Glis glis) and their fleas as reservoirs for Bartonella spp.

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Edible dormice (Glis glis) and their fleas as reservoirs for Bartonella spp.

Popis výsledku v původním jazyce

Bartonellosis is a group of emerging infectious diseases caused by facultatively intraerythrocytic bacteria transmitted between vertebrate hosts by arthropod vectors. Although only some Bartonella spp. are traditionally associated with human diseases, it was proposed, that virtually any species can have zoonotic potential. The highest species diversity was described from rodents acting as reservoirs with prevalence ranging from 40 to 70 % all over the world. Fleas associated with mammalian hosts play an important role in the Bartonella lifecycle and are described to act not only as competent vectors but also as reservoirs of several species. The role of edible dormice (Glis glis), which often interact with humans, and their fleas in Bartonella transmission and lifecycle has been so far unknown; therefore, the prevalence and diversity of Bartonella spp. in edible dormice in the Czech Republic was studied. Complementary PCR analysis of four loci (gltA, rpoB, ftsZ, ITS), MALDI-TOF, and cultivation was performed to identify Bartonella infections. The prevalence reaching 90 % was found in both, dormice and their fleas. Altogether four species of Bartonella and several genotypes were determined; two species were cultivated and further characterized by transmission electron microscopy and biochemical analysis. These results provide the first thorough insights into the potential of the edible dormouse as a host and reservoir of Bartonella species and the zoonotic potential.

Název v anglickém jazyce

Edible dormice (Glis glis) and their fleas as reservoirs for Bartonella spp.

Popis výsledku anglicky

Bartonellosis is a group of emerging infectious diseases caused by facultatively intraerythrocytic bacteria transmitted between vertebrate hosts by arthropod vectors. Although only some Bartonella spp. are traditionally associated with human diseases, it was proposed, that virtually any species can have zoonotic potential. The highest species diversity was described from rodents acting as reservoirs with prevalence ranging from 40 to 70 % all over the world. Fleas associated with mammalian hosts play an important role in the Bartonella lifecycle and are described to act not only as competent vectors but also as reservoirs of several species. The role of edible dormice (Glis glis), which often interact with humans, and their fleas in Bartonella transmission and lifecycle has been so far unknown; therefore, the prevalence and diversity of Bartonella spp. in edible dormice in the Czech Republic was studied. Complementary PCR analysis of four loci (gltA, rpoB, ftsZ, ITS), MALDI-TOF, and cultivation was performed to identify Bartonella infections. The prevalence reaching 90 % was found in both, dormice and their fleas. Altogether four species of Bartonella and several genotypes were determined; two species were cultivated and further characterized by transmission electron microscopy and biochemical analysis. These results provide the first thorough insights into the potential of the edible dormouse as a host and reservoir of Bartonella species and the zoonotic potential.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

40301 - Veterinary science

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů