The occurrence of preclinical dilated cardiomyopathy in the Weimaraner dog breed and the prognostic importance of cardiac markers

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F24%3A43881354" target="_blank" >RIV/62157124:16170/24:43881354 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62157124:16270/24:43881354

Výsledek na webu

<a href="http://chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://actavet.vfu.cz/media/pdf/actavet_2024093040397.pdf" target="_blank" >http://chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://actavet.vfu.cz/media/pdf/actavet_2024093040397.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2754/avb202493040397" target="_blank" >10.2754/avb202493040397</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The occurrence of preclinical dilated cardiomyopathy in the Weimaraner dog breed and the prognostic importance of cardiac markers

Popis výsledku v původním jazyce

Dilated cardiomyopathy (DCM) is a major cause of morbidity and mortality in various dog breeds, being the second most common acquired cardiac disease in dogs. The most frequently affected breeds are Doberman Pinchers, Great Danes, Boxers, Irish Wolfhounds and others. We found out that the Weimaraner breed also suffers from this disease. Prospective dog screening may identify animals with DCM at Stage B. In the study, a total of 331 dogs of the Weimaraner breed were enrolled. Of the total number, 300 dogs were healthy. Seventeen dogs were diagnosed with preclinical DCM. The cut-off value for preclinical DCM of NTproBNP (N-terminal prohormone of brain natriuretic peptide) was 405 pmol/l, sensitivity was 73% and specificity was 72%. The cut-off value for preclinical DCM of troponin I was 0.04 ng/ml, sensitivity was 66% and specificity was 88%. This is the first study to evaluate the use of NTproBNP and cTnI as markers of preclinical DCM in Weimaraners. Setting the cut-off values for these parameters shows its clinical validity in detecting the disease, such as the possibility of using these tests in routine clinical practice.

Název v anglickém jazyce

The occurrence of preclinical dilated cardiomyopathy in the Weimaraner dog breed and the prognostic importance of cardiac markers

Popis výsledku anglicky

Dilated cardiomyopathy (DCM) is a major cause of morbidity and mortality in various dog breeds, being the second most common acquired cardiac disease in dogs. The most frequently affected breeds are Doberman Pinchers, Great Danes, Boxers, Irish Wolfhounds and others. We found out that the Weimaraner breed also suffers from this disease. Prospective dog screening may identify animals with DCM at Stage B. In the study, a total of 331 dogs of the Weimaraner breed were enrolled. Of the total number, 300 dogs were healthy. Seventeen dogs were diagnosed with preclinical DCM. The cut-off value for preclinical DCM of NTproBNP (N-terminal prohormone of brain natriuretic peptide) was 405 pmol/l, sensitivity was 73% and specificity was 72%. The cut-off value for preclinical DCM of troponin I was 0.04 ng/ml, sensitivity was 66% and specificity was 88%. This is the first study to evaluate the use of NTproBNP and cTnI as markers of preclinical DCM in Weimaraners. Setting the cut-off values for these parameters shows its clinical validity in detecting the disease, such as the possibility of using these tests in routine clinical practice.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

40301 - Veterinary science

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta veterinaria Brno

ISSN

0001-7213

e-ISSN

1801-7576

Svazek periodika

93

Číslo periodika v rámci svazku

40

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

8

Strana od-do

397-404

Kód UT WoS článku

001390178500007

EID výsledku v databázi Scopus

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