Acute Kidney Injury in Horses as a Consequence of Treatment with Suxibuzone.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F24%3A43881466" target="_blank" >RIV/62157124:16170/24:43881466 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.2754/avb202493020135" target="_blank" >https://doi.org/10.2754/avb202493020135</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2754/avb202493020135" target="_blank" >10.2754/avb202493020135</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Acute Kidney Injury in Horses as a Consequence of Treatment with Suxibuzone.

Popis výsledku v původním jazyce

Suxibuzone is a prodrug of the nonsteroidal anti-inflammatory drug phenylbutazone. The aim of this study was to investigate the nephrotoxicity of suxibuzone using the recommended dosage in euhydrated horses. Serum creatinine levels were used to monitor for the presenceof acute kidney injury (AKI) in 11 systemically healthy horses treated orally with suxibuzone at the recommended dosage for five days. Symmetric dimethylarginine (SDMA), urine gamma glutamyl transferase/urine creatinine, fractional excretion of sodium, urine protein-to-creatinine ratio, and urine sediment were assessed as additional monitoring parameters. A significant increase in creatinine was found in treated horses (P = 0.002), 27% (3/11) of treated horses were classified as having AKI compared to 0% of controls (0/10), and a strong correlation was found between the change in creatinine and the change in SDMA in treated horses (τ = 0.645,P = 0.012). The results of this study suggest that treatment with suxibuzone at the recommended dosage can induce AKI even in systemically healthy euhydrated horses.

Název v anglickém jazyce

Acute Kidney Injury in Horses as a Consequence of Treatment with Suxibuzone.

Popis výsledku anglicky

Suxibuzone is a prodrug of the nonsteroidal anti-inflammatory drug phenylbutazone. The aim of this study was to investigate the nephrotoxicity of suxibuzone using the recommended dosage in euhydrated horses. Serum creatinine levels were used to monitor for the presenceof acute kidney injury (AKI) in 11 systemically healthy horses treated orally with suxibuzone at the recommended dosage for five days. Symmetric dimethylarginine (SDMA), urine gamma glutamyl transferase/urine creatinine, fractional excretion of sodium, urine protein-to-creatinine ratio, and urine sediment were assessed as additional monitoring parameters. A significant increase in creatinine was found in treated horses (P = 0.002), 27% (3/11) of treated horses were classified as having AKI compared to 0% of controls (0/10), and a strong correlation was found between the change in creatinine and the change in SDMA in treated horses (τ = 0.645,P = 0.012). The results of this study suggest that treatment with suxibuzone at the recommended dosage can induce AKI even in systemically healthy euhydrated horses.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

40301 - Veterinary science

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta veterinaria Brno

ISSN

0001-7213

e-ISSN

1801-7576

Svazek periodika

93

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

6

Strana od-do

135-140

Kód UT WoS článku

001262617300003

EID výsledku v databázi Scopus

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