Urinary protein-to-creatinine ratio in guinea pigs (Cavia porcellus): Reference range and the effect of age and sex

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F25%3A43882725" target="_blank" >RIV/62157124:16170/25:43882725 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62157124:16270/25:43882725

Výsledek na webu

<a href="https://bvajournals.onlinelibrary.wiley.com/doi/epdf/10.1002/vetr.4911" target="_blank" >https://bvajournals.onlinelibrary.wiley.com/doi/epdf/10.1002/vetr.4911</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/vetr.4911" target="_blank" >10.1002/vetr.4911</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Urinary protein-to-creatinine ratio in guinea pigs (Cavia porcellus): Reference range and the effect of age and sex

Popis výsledku v původním jazyce

BackgroundThere are currently few reports on the normal urinary protein-to-creatinine (UPC) ratio of guinea pigs, and there is little information on the effects of age and sex on this parameter.MethodsUrinary protein and creatinine concentrations were measured in a total of 161 clinically healthy guinea pigs, and the UPC ratio was subsequently calculated. The effect of age and sex on these parameters was assessed using Mann-Whitney U tests. Using these data, UPC ratio reference ranges were established.ResultsGuinea pig pups younger than 6 months had a significantly higher UPC ratio than adult animals (median UPCs of 1.48 and 0.56, respectively). There was no effect of sex on this parameter. The reference range for the UPC ratio in adult guinea pigs was set at 0.12-2.21. For guinea pigs younger than 6 months, the reference range for the UPC ratio was set at 0.4-3.1.LimitationsThis study was limited by the lack of blood analysis, which could reveal a subclinical health problem that could affect renal function and the extent of proteinuria.ConclusionIn guinea pigs, the UPC ratio is influenced by age but not by sex. Therefore, the reference range established for adult guinea pigs cannot be used for pups younger than 6 months.

Název v anglickém jazyce

Urinary protein-to-creatinine ratio in guinea pigs (Cavia porcellus): Reference range and the effect of age and sex

Popis výsledku anglicky

BackgroundThere are currently few reports on the normal urinary protein-to-creatinine (UPC) ratio of guinea pigs, and there is little information on the effects of age and sex on this parameter.MethodsUrinary protein and creatinine concentrations were measured in a total of 161 clinically healthy guinea pigs, and the UPC ratio was subsequently calculated. The effect of age and sex on these parameters was assessed using Mann-Whitney U tests. Using these data, UPC ratio reference ranges were established.ResultsGuinea pig pups younger than 6 months had a significantly higher UPC ratio than adult animals (median UPCs of 1.48 and 0.56, respectively). There was no effect of sex on this parameter. The reference range for the UPC ratio in adult guinea pigs was set at 0.12-2.21. For guinea pigs younger than 6 months, the reference range for the UPC ratio was set at 0.4-3.1.LimitationsThis study was limited by the lack of blood analysis, which could reveal a subclinical health problem that could affect renal function and the extent of proteinuria.ConclusionIn guinea pigs, the UPC ratio is influenced by age but not by sex. Therefore, the reference range established for adult guinea pigs cannot be used for pups younger than 6 months.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

40301 - Veterinary science

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Veterinary Record

ISSN

0042-4900

e-ISSN

2042-7670

Svazek periodika

196

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

nestránkováno

Kód UT WoS článku

001383116600001

EID výsledku v databázi Scopus

—