Susceptibility of selected murine and microtine species to infection by a wild-strain Francisella tularensis subsp. holarctica.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F09%3A00002236" target="_blank" >RIV/62157124:16270/09:00002236 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Susceptibility of selected murine and microtine species to infection by a wild-strain Francisella tularensis subsp. holarctica.

Popis výsledku v původním jazyce

The purpose of this study was to compare susceptibility of BALB/c mice, common voles (Microtus arvalis) and yellow-necked mice (Apodemus flavicollis) to infection by a virulent Francisella tularensis subsp. holarctica strain. Median survival in these three species following experimental infection with 320 colony forming units of F. tularensis (both intraperitoneally and subcutaneously) amounted to 4.5, 7 and 4 days, respectively. Survival curves of BALB/c and yellow-necked mice were very similar and were significantly different from that of common voles. LD50 was 0.5 and 37.9 colony forming units in BALB/c mice and common voles, respectively. The bacterial burden in the spleen, liver, lung, kidney and blood of common voles started to develop later postexposure and amounted to lower levels (except in kidneys) than in BALB/c mice. The results demonstrate that yellow-necked mice are even more susceptible to infection by F. tularensis than BALB/c mice and that the common vole is a small m

Název v anglickém jazyce

Susceptibility of selected murine and microtine species to infection by a wild-strain Francisella tularensis subsp. holarctica.

Popis výsledku anglicky

The purpose of this study was to compare susceptibility of BALB/c mice, common voles (Microtus arvalis) and yellow-necked mice (Apodemus flavicollis) to infection by a virulent Francisella tularensis subsp. holarctica strain. Median survival in these three species following experimental infection with 320 colony forming units of F. tularensis (both intraperitoneally and subcutaneously) amounted to 4.5, 7 and 4 days, respectively. Survival curves of BALB/c and yellow-necked mice were very similar and were significantly different from that of common voles. LD50 was 0.5 and 37.9 colony forming units in BALB/c mice and common voles, respectively. The bacterial burden in the spleen, liver, lung, kidney and blood of common voles started to develop later postexposure and amounted to lower levels (except in kidneys) than in BALB/c mice. The results demonstrate that yellow-necked mice are even more susceptible to infection by F. tularensis than BALB/c mice and that the common vole is a small m

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Veterinární medicína

ISSN

0375-8427

e-ISSN

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Svazek periodika

54

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

11

Strana od-do

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Kód UT WoS článku

000264217300003

EID výsledku v databázi Scopus

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