Effects of mixture of pharmaceuticals on early life stages of tench (Tinca tinca)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F14%3A43872886" target="_blank" >RIV/62157124:16270/14:43872886 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68081766:_____/14:00427896 RIV/62157124:16170/14:43872886

Výsledek na webu

<a href="http://dx.doi.org/10.1155/2014/253468" target="_blank" >http://dx.doi.org/10.1155/2014/253468</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2014/253468" target="_blank" >10.1155/2014/253468</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effects of mixture of pharmaceuticals on early life stages of tench (Tinca tinca)

Popis výsledku v původním jazyce

Ubiquitous occurrence of pharmaceuticals in aquatic environment results in concern about potential adverse the effects on nontarget organisms. In water, drugs are present in complex mixtures, in which complicated interactions affect toxicity of single components. The purpose of this study was to examine effect of 35-day-long exposure to mixture of ibuprofen, diclofenac, and carbamazepine on the mortality, growth, early ontogeny, and histopathological changes in tench (Tinca tinca). Early life stage toxicity test was carried out using a modified protocol according to OECD guideline 210. Exposure to mixture of pharmaceuticals at concentration of 60 mu g.L-1 for each substance was associated with significant increase in mortality, as well as significant increase in growth and elevated incidence of malformations. Any of the tested concentrations resulted in histopathological changes of liver, kidney, skin, or gill. After fourteen days of exposure there was short-termdelay of development re

Název v anglickém jazyce

Effects of mixture of pharmaceuticals on early life stages of tench (Tinca tinca)

Popis výsledku anglicky

Ubiquitous occurrence of pharmaceuticals in aquatic environment results in concern about potential adverse the effects on nontarget organisms. In water, drugs are present in complex mixtures, in which complicated interactions affect toxicity of single components. The purpose of this study was to examine effect of 35-day-long exposure to mixture of ibuprofen, diclofenac, and carbamazepine on the mortality, growth, early ontogeny, and histopathological changes in tench (Tinca tinca). Early life stage toxicity test was carried out using a modified protocol according to OECD guideline 210. Exposure to mixture of pharmaceuticals at concentration of 60 mu g.L-1 for each substance was associated with significant increase in mortality, as well as significant increase in growth and elevated incidence of malformations. Any of the tested concentrations resulted in histopathological changes of liver, kidney, skin, or gill. After fourteen days of exposure there was short-termdelay of development re

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

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Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomed Research International

ISSN

2314-6133

e-ISSN

—

Svazek periodika

2014

Číslo periodika v rámci svazku

2014

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

253468

Kód UT WoS článku

000333627400001

EID výsledku v databázi Scopus

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