Antimicrobial Properties of Microparticles Based on Carmellose Cross-Linked by Cu2+ Ions
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F15%3A43873515" target="_blank" >RIV/62157124:16270/15:43873515 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/62157124:16170/15:43873515 RIV/62157124:16370/15:43873515
Výsledek na webu
<a href="http://dx.doi.org/10.1155/2015/790720" target="_blank" >http://dx.doi.org/10.1155/2015/790720</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2015/790720" target="_blank" >10.1155/2015/790720</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Antimicrobial Properties of Microparticles Based on Carmellose Cross-Linked by Cu2+ Ions
Popis výsledku v původním jazyce
Carmellose (CMC) is frequently used due to its high biocompatibility, biodegradability, and low immunogenicity for development of site-specific or controlled release drug delivery systems. In this experimental work, CMC dispersions in two different concentrations (1% and 2%) cross-linked by copper (II) ions (0.5, 1, 1.5, or 2.0 M CuCl2) were used to prepare microspheres with antimicrobial activity against Escherichia coli and Candida albicans, both frequently occurring pathogens which cause vaginal infections. The microparticles were prepared by an ionotropic gelation technique which offers the unique possibility to entrap divalent copper ions in a CMC structure and thus ensure their antibacterial activity. Prepared CMC microspheres exhibited sufficient sphericity. Both equivalent diameter and copper content were influenced by CMC concentration, and the molarity of copper (II) solution affected only the copper content results. Selected samples exhibited stable but pH-responsive behavio
Název v anglickém jazyce
Antimicrobial Properties of Microparticles Based on Carmellose Cross-Linked by Cu2+ Ions
Popis výsledku anglicky
Carmellose (CMC) is frequently used due to its high biocompatibility, biodegradability, and low immunogenicity for development of site-specific or controlled release drug delivery systems. In this experimental work, CMC dispersions in two different concentrations (1% and 2%) cross-linked by copper (II) ions (0.5, 1, 1.5, or 2.0 M CuCl2) were used to prepare microspheres with antimicrobial activity against Escherichia coli and Candida albicans, both frequently occurring pathogens which cause vaginal infections. The microparticles were prepared by an ionotropic gelation technique which offers the unique possibility to entrap divalent copper ions in a CMC structure and thus ensure their antibacterial activity. Prepared CMC microspheres exhibited sufficient sphericity. Both equivalent diameter and copper content were influenced by CMC concentration, and the molarity of copper (II) solution affected only the copper content results. Selected samples exhibited stable but pH-responsive behavio
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FR - Farmakologie a lékárnická chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Biomed Research International
ISSN
2314-6133
e-ISSN
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Svazek periodika
Neuveden
Číslo periodika v rámci svazku
2015
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
9
Strana od-do
"Nestránkováno"
Kód UT WoS článku
000355513200001
EID výsledku v databázi Scopus
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