Appraisal of a synthetic preservative, Quaternium-15, effect on three model organisms: new insight on environmental risks

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F24%3A43881741" target="_blank" >RIV/62157124:16270/24:43881741 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1016/j.aquatox.2024.107138" target="_blank" >https://doi.org/10.1016/j.aquatox.2024.107138</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.aquatox.2024.107138" target="_blank" >10.1016/j.aquatox.2024.107138</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Appraisal of a synthetic preservative, Quaternium-15, effect on three model organisms: new insight on environmental risks

Popis výsledku v původním jazyce

After the COVID-19 pandemic, the use of quaternary ammonium compounds increased exponentially due to their efficacy as antimicrobials, stabilizers and disinfectants. Among these, Quaternium-15 is a preservative used in the formulation of a variety of personal care products. The increased use of this substance and the resulting persistence in wastewater treatment systems, which are unable to completely remove the Quaternium-15 from the water, is of increasing environmental concern. Using embryotoxicity analyses, this study aimed to investigate the effects of exposure to Quaternium-15 on non-target species and the resulting risks to the environment. Embryotoxicity endpoints such as mortality, hatching, presence of malformations, altered heartbeat and animal length were used to assess the effects on three model organisms (Cyprinus carpio, Danio rerio, Xenopus laevis) were evaluated during a 96-hour exposure to six different concentrations of Quaternium-15 (1, 5, 10, 15, 20 and 25 mg/L). The results obtained from the analyses highlighted: significant mortality for all three model organisms in the highest concentrations tested in which all the embryos died after 96 hpf, a delay in hatching of C. carpio and D. rerio compared to the control group, the insurgence of malformations in all the model organisms chosen and a significant decrease in heartbeat rate for the fish models. Each of these observations underlies the negative interaction between the Quaternium-15 and aquatic organisms making necessary further investigation to prevent damage to ecosystems and non-target species.

Název v anglickém jazyce

Appraisal of a synthetic preservative, Quaternium-15, effect on three model organisms: new insight on environmental risks

Popis výsledku anglicky

After the COVID-19 pandemic, the use of quaternary ammonium compounds increased exponentially due to their efficacy as antimicrobials, stabilizers and disinfectants. Among these, Quaternium-15 is a preservative used in the formulation of a variety of personal care products. The increased use of this substance and the resulting persistence in wastewater treatment systems, which are unable to completely remove the Quaternium-15 from the water, is of increasing environmental concern. Using embryotoxicity analyses, this study aimed to investigate the effects of exposure to Quaternium-15 on non-target species and the resulting risks to the environment. Embryotoxicity endpoints such as mortality, hatching, presence of malformations, altered heartbeat and animal length were used to assess the effects on three model organisms (Cyprinus carpio, Danio rerio, Xenopus laevis) were evaluated during a 96-hour exposure to six different concentrations of Quaternium-15 (1, 5, 10, 15, 20 and 25 mg/L). The results obtained from the analyses highlighted: significant mortality for all three model organisms in the highest concentrations tested in which all the embryos died after 96 hpf, a delay in hatching of C. carpio and D. rerio compared to the control group, the insurgence of malformations in all the model organisms chosen and a significant decrease in heartbeat rate for the fish models. Each of these observations underlies the negative interaction between the Quaternium-15 and aquatic organisms making necessary further investigation to prevent damage to ecosystems and non-target species.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

40301 - Veterinary science

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Aquatic toxicology

ISSN

0166-445X

e-ISSN

1879-1514

Svazek periodika

277

Číslo periodika v rámci svazku

December

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

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Kód UT WoS článku

001349834700001

EID výsledku v databázi Scopus

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