Effect of gabapentin-lactam on early developmental stages of zebrafish (Danio rerio) – behavioural study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F25%3A43882710" target="_blank" >RIV/62157124:16270/25:43882710 - isvavai.cz</a>

Výsledek na webu

<a href="https://obd.vfu.cz/fcgi/verso.fpl/_TS_/1773386984?fname=dload&idfile=3015056" target="_blank" >https://obd.vfu.cz/fcgi/verso.fpl/_TS_/1773386984?fname=dload&idfile=3015056</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Effect of gabapentin-lactam on early developmental stages of zebrafish (Danio rerio) – behavioural study

Popis výsledku v původním jazyce

Gabapentin-lactam (GBP-L), a transformation product of the widely used anticonvulsant gabapentin (GBP), is formed by intramolecular cyclisation. It is often detected in aquatic environments due to its high chemical stability and poor biodegradability. Although the parent compound has been thoroughly studied, the ecotoxicological effects of GBP-L are not well understood, particularly at environmentally relevant concentrations. This study investigates the effects of GBP-L on the behaviour of zebrafish (Danio rerio) larvae following exposure to two concentrations: 1.5 μg/L and 100 μg/L. The results revealed a notable increase in total swimming distance in both groups compared to the control group. Both groups exposed to GBP-L exhibited increased activity during both the light and dark phases, indicating a disruption to normal behavioural patterns. While these results are consistent with previous findings for gabapentin, the reversed concentration-response pattern suggests differences in pharmacodynamics or toxicity thresholds between the two compounds. To our knowledge, this is the first study to demonstrate behavioural changes in zebrafish due to exposure to GBP-L. These findings highlight the importance of including pharmaceutical transformation products in environmental risk assessments, and further research is needed to understand their mechanisms of action

Název v anglickém jazyce

Effect of gabapentin-lactam on early developmental stages of zebrafish (Danio rerio) – behavioural study

Popis výsledku anglicky

Gabapentin-lactam (GBP-L), a transformation product of the widely used anticonvulsant gabapentin (GBP), is formed by intramolecular cyclisation. It is often detected in aquatic environments due to its high chemical stability and poor biodegradability. Although the parent compound has been thoroughly studied, the ecotoxicological effects of GBP-L are not well understood, particularly at environmentally relevant concentrations. This study investigates the effects of GBP-L on the behaviour of zebrafish (Danio rerio) larvae following exposure to two concentrations: 1.5 μg/L and 100 μg/L. The results revealed a notable increase in total swimming distance in both groups compared to the control group. Both groups exposed to GBP-L exhibited increased activity during both the light and dark phases, indicating a disruption to normal behavioural patterns. While these results are consistent with previous findings for gabapentin, the reversed concentration-response pattern suggests differences in pharmacodynamics or toxicity thresholds between the two compounds. To our knowledge, this is the first study to demonstrate behavioural changes in zebrafish due to exposure to GBP-L. These findings highlight the importance of including pharmaceutical transformation products in environmental risk assessments, and further research is needed to understand their mechanisms of action

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

40301 - Veterinary science

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Ochrana zvířat a welfare 2025: Sborník příspěvků

ISBN

978-80-7305-996-5

ISSN

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e-ISSN

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Počet stran výsledku

5

Strana od-do

521-525

Název nakladatele

Veterinární univerzita Brno

Místo vydání

Brno

Místo konání akce

Brno

Datum konání akce

2. 10. 2025

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

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