Study of Protective Effects of Beta-blocker Carvedilol by Experimentally Induced Solar Burn in Rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F01%3A00000690" target="_blank" >RIV/62157124:16370/01:00000690 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62157124:16370/01:00000686

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Study of Protective Effects of Beta-blocker Carvedilol by Experimentally Induced Solar Burn in Rats

Popis výsledku v původním jazyce

Evidence that free oxygen radicals may be responsible for tissue damage following skin thermal injury supports a theory of interventional use of antioxidants in therapy. Carvedilol (CVD) is used for treatment of hypertension and chronic heart failure. Further it shows a potent scavenger property in pathological conditions, in which free oxygen radicals (FOR) take part. We studied whether carvedilol can reduce renal damage induced by solar thermal effect in 17 days-long experiment. By the applicationof solar emittor we developed the solar erythema within the range 30% of the total body surface of experimental rats. Animals were randomised into two equal groups (n = 7). The first group treated with CVD at the dose 10mg/kg/day administered in 1ml sal inei.p. The placebo group was given 1 ml saline i.p./day. Serum samples for evaluating proteins and malonyldialdehyde (MDA) were obtained the 1st, 8th and 17th day. Urine samples were taken daily to measure proteinuria and total protein loss

Název v anglickém jazyce

Study of Protective Effects of Beta-blocker Carvedilol by Experimentally Induced Solar Burn in Rats

Popis výsledku anglicky

Evidence that free oxygen radicals may be responsible for tissue damage following skin thermal injury supports a theory of interventional use of antioxidants in therapy. Carvedilol (CVD) is used for treatment of hypertension and chronic heart failure. Further it shows a potent scavenger property in pathological conditions, in which free oxygen radicals (FOR) take part. We studied whether carvedilol can reduce renal damage induced by solar thermal effect in 17 days-long experiment. By the applicationof solar emittor we developed the solar erythema within the range 30% of the total body surface of experimental rats. Animals were randomised into two equal groups (n = 7). The first group treated with CVD at the dose 10mg/kg/day administered in 1ml sal inei.p. The placebo group was given 1 ml saline i.p./day. Serum samples for evaluating proteins and malonyldialdehyde (MDA) were obtained the 1st, 8th and 17th day. Urine samples were taken daily to measure proteinuria and total protein loss

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2001

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta veterinaria

ISSN

0001-7213

e-ISSN

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Svazek periodika

70

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

5

Strana od-do

397-401

Kód UT WoS článku

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EID výsledku v databázi Scopus

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