Native and Derivated Prenylisoflavones

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Native and Derivated Prenylisoflavones

Popis výsledku v původním jazyce

Naturally occuring prenylflavonoids, distributed in plants, are very popular for their various biological activities. Two prenylisoflavones osajin (I) and pomiferin (II) were isolated from the fruits of Maclura pomifera (Moraceae) and identified by spectral analysis [1]. Iso-osajin (III) and iso-pomiferin (IV) were prepared from native isoflavones by reaction of native compounds with formic acid. Cyclization of prenyl chain in position 6 with hydroxyl group in position 5 leads to the new dimethylpyranering. Antioxidant activity of all these compounds was evaluated using methods with 1,1-difenyl-2-picrylhydrazyl (DPPH) and 2,2-azino-bis(3-ethylbenzthiazolin)-6-sulfonic acid (ABTS+). Compounds III and IV exhibit decrease of antioxidant activity. From Iand II were prepared two bromderivates by halogenation and separation using flash chromatography. These compounds are tested for their antifungal properties.

Název v anglickém jazyce

Native and Derivated Prenylisoflavones

Popis výsledku anglicky

Naturally occuring prenylflavonoids, distributed in plants, are very popular for their various biological activities. Two prenylisoflavones osajin (I) and pomiferin (II) were isolated from the fruits of Maclura pomifera (Moraceae) and identified by spectral analysis [1]. Iso-osajin (III) and iso-pomiferin (IV) were prepared from native isoflavones by reaction of native compounds with formic acid. Cyclization of prenyl chain in position 6 with hydroxyl group in position 5 leads to the new dimethylpyranering. Antioxidant activity of all these compounds was evaluated using methods with 1,1-difenyl-2-picrylhydrazyl (DPPH) and 2,2-azino-bis(3-ethylbenzthiazolin)-6-sulfonic acid (ABTS+). Compounds III and IV exhibit decrease of antioxidant activity. From Iand II were prepared two bromderivates by halogenation and separation using flash chromatography. These compounds are tested for their antifungal properties.

Druh

D - Stať ve sborníku

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2004

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Sborník abstrakt - 3rd Conference on Medicinal and Aromatic Plants of Southeast European Countries

ISBN

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ISSN

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e-ISSN

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Počet stran výsledku

1

Strana od-do

79

Název nakladatele

Slovak University of Agriculture in Nitra

Místo vydání

Nitra

Místo konání akce

Nitra

Datum konání akce

5. 9. 2004

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

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