Effect of Stereoisomery on Antiarrhythmic Impact of Newly Synthesized Compound 44Bu

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F08%3A00002550" target="_blank" >RIV/62157124:16370/08:00002550 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Effect of Stereoisomery on Antiarrhythmic Impact of Newly Synthesized Compound 44Bu

Popis výsledku v původním jazyce

S-isomer and racemate significantly (P<0.01) decrease the occurrence of dangerous types of arrhythmias, such as ventricular tachycardia and ventricular fibrillation against control. Racemate is better than S-isomer but nonsignificantly. Unfortunately itseems, that racemate induces AV blockades. R-isomer proved the pure antiarrhythmic effect, but differences between isomers were nonsignificant. All forms of the 44Bu have an ability to delay the start of arrhythmias. The best postponing effect have racemate and then S-isomer. R-isomer had the smallest impact. After the prophylactic administration of the tested substances the profile (composition) of individual arrhythmia types changed, which is very beneficial, especially when the occurrence of the mostdangerous arrhythmias decreases. Racemate and S-isomer have the best decrease on the mortality reduction of aconitine intoxicated animals.

Název v anglickém jazyce

Effect of Stereoisomery on Antiarrhythmic Impact of Newly Synthesized Compound 44Bu

Popis výsledku anglicky

S-isomer and racemate significantly (P<0.01) decrease the occurrence of dangerous types of arrhythmias, such as ventricular tachycardia and ventricular fibrillation against control. Racemate is better than S-isomer but nonsignificantly. Unfortunately itseems, that racemate induces AV blockades. R-isomer proved the pure antiarrhythmic effect, but differences between isomers were nonsignificant. All forms of the 44Bu have an ability to delay the start of arrhythmias. The best postponing effect have racemate and then S-isomer. R-isomer had the smallest impact. After the prophylactic administration of the tested substances the profile (composition) of individual arrhythmia types changed, which is very beneficial, especially when the occurrence of the mostdangerous arrhythmias decreases. Racemate and S-isomer have the best decrease on the mortality reduction of aconitine intoxicated animals.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Prague Medical Report

ISSN

1214-6994

e-ISSN

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Svazek periodika

109

Číslo periodika v rámci svazku

Suppl.1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

4

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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