Coated hard capsules as the pH-dependent drug transport systems to ileo-colonic compartment

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F11%3A43870238" target="_blank" >RIV/62157124:16370/11:43870238 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.3109/03639045.2011.561350" target="_blank" >http://dx.doi.org/10.3109/03639045.2011.561350</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3109/03639045.2011.561350" target="_blank" >10.3109/03639045.2011.561350</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Coated hard capsules as the pH-dependent drug transport systems to ileo-colonic compartment

Popis výsledku v původním jazyce

Purpose: The aim of this study was to investigate the suitability of hard capsules of different composition (gelatin-G, gelatin coated with hydroxypropyl cellulose-G/HPC, and hypromellose-H) for a coating with aqueous dispersion of pH-dependent syntheticpolymer Eudragit (R) FS (E(FS)) and to evaluate in vitro the coated capsules as transport systems for ileo-colonic drug delivery. Methods: Three sets of hard capsules with increasing coating levels (5-30%) were obtained by Wurster technique. The releaseof model drug (caffeine) from prepared samples was tested using paddle dissolution method with continual pH change (pH 1.2-2 h, 6.8-4 h and 7.5-2 h). Results: During the coating process, no problems occurred and similar suitability of capsules materialsfor E(FS) application was observed in contrast to some published reports. The application of HPC subcoating onto gelatin capsules surface was shown as the redundant step. The samples G/E(FS) 10-15% and H/E(FS) 15-20% with 6 h lag time an

Název v anglickém jazyce

Coated hard capsules as the pH-dependent drug transport systems to ileo-colonic compartment

Popis výsledku anglicky

Purpose: The aim of this study was to investigate the suitability of hard capsules of different composition (gelatin-G, gelatin coated with hydroxypropyl cellulose-G/HPC, and hypromellose-H) for a coating with aqueous dispersion of pH-dependent syntheticpolymer Eudragit (R) FS (E(FS)) and to evaluate in vitro the coated capsules as transport systems for ileo-colonic drug delivery. Methods: Three sets of hard capsules with increasing coating levels (5-30%) were obtained by Wurster technique. The releaseof model drug (caffeine) from prepared samples was tested using paddle dissolution method with continual pH change (pH 1.2-2 h, 6.8-4 h and 7.5-2 h). Results: During the coating process, no problems occurred and similar suitability of capsules materialsfor E(FS) application was observed in contrast to some published reports. The application of HPC subcoating onto gelatin capsules surface was shown as the redundant step. The samples G/E(FS) 10-15% and H/E(FS) 15-20% with 6 h lag time an

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/NS10222" target="_blank" >NS10222: Mikročásticová léková forma pro terapii nespecifických střevních zánětlivých onemocnění</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Drug Development and Industrial Pharmacy

ISSN

0363-9045

e-ISSN

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Svazek periodika

37

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

1131-1140

Kód UT WoS článku

000294862600001

EID výsledku v databázi Scopus

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