Investigation of antiradical activity of Salvia officinalis L., Urtica dioica L., and Thymus vulgaris L. extracts as potential candidates for a complex therapeutic preparation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F11%3A43870420" target="_blank" >RIV/62157124:16370/11:43870420 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.5897/JMPR11.1177" target="_blank" >http://dx.doi.org/10.5897/JMPR11.1177</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5897/JMPR11.1177" target="_blank" >10.5897/JMPR11.1177</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Investigation of antiradical activity of Salvia officinalis L., Urtica dioica L., and Thymus vulgaris L. extracts as potential candidates for a complex therapeutic preparation

Popis výsledku v původním jazyce

The aim of this study was to investigate free radical-scavenging activity of Salvia officinalis L., Thymus vulgaris L., Urtica dioica L. extracts and mixture of extracts, and to evaluate the effect of these extracts on the ability of mitochondria to generate free radicals. The evaluation of the activity of extracts using 2,2-diphenyl-1-picrylhydrazyl (DDPH), 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS) radicals scavenging assays and tyrosine nitration inhibition (TNI) techniques showed thatthyme extract had the strongest free-radical-scavenging activity. This extract was also found to contain the highest amount of phenols. Mixture of extracts showed slow and identical DPPH and ABTS radical-scavenging activity, with the strongest activitydemonstrated during the first minute. Investigation of the ability of extracts to neutralize hydrogen peroxide showed that the lowest extract amount used (0.01 mg) neutralized 24 to 50% and the highest amount (0.1 mg) - 72 to 88% of H(2)O

Název v anglickém jazyce

Investigation of antiradical activity of Salvia officinalis L., Urtica dioica L., and Thymus vulgaris L. extracts as potential candidates for a complex therapeutic preparation

Popis výsledku anglicky

The aim of this study was to investigate free radical-scavenging activity of Salvia officinalis L., Thymus vulgaris L., Urtica dioica L. extracts and mixture of extracts, and to evaluate the effect of these extracts on the ability of mitochondria to generate free radicals. The evaluation of the activity of extracts using 2,2-diphenyl-1-picrylhydrazyl (DDPH), 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS) radicals scavenging assays and tyrosine nitration inhibition (TNI) techniques showed thatthyme extract had the strongest free-radical-scavenging activity. This extract was also found to contain the highest amount of phenols. Mixture of extracts showed slow and identical DPPH and ABTS radical-scavenging activity, with the strongest activitydemonstrated during the first minute. Investigation of the ability of extracts to neutralize hydrogen peroxide showed that the lowest extract amount used (0.01 mg) neutralized 24 to 50% and the highest amount (0.1 mg) - 72 to 88% of H(2)O

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Medicinal Plants Research

ISSN

1996-0875

e-ISSN

—

Svazek periodika

5

Číslo periodika v rámci svazku

25

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

6090-6096

Kód UT WoS článku

000297462000023

EID výsledku v databázi Scopus

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