Azone Analogues: Classification, Design, and Transdermal Penetration Principles

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F12%3A43871548" target="_blank" >RIV/62157124:16370/12:43871548 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1002/med.20227" target="_blank" >http://dx.doi.org/10.1002/med.20227</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/med.20227" target="_blank" >10.1002/med.20227</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Azone Analogues: Classification, Design, and Transdermal Penetration Principles

Popis výsledku v původním jazyce

The development in the field of pharmaceutical dosage forms results in the discovery of additional highly sophisticated drug delivery systems that allow maintaining a constant level of the active substance in an organism. Transdermal therapeutic systemsare an excellent alternative to conventional pharmaceutical dosage forms. However, the application of transdermal drug delivery faces the problem of insufficient or no penetration of active pharmaceutical substances through the skin. This review articledescribes the possible fundamental mechanisms of penetration through the skin barrier and refers to the classification of skin penetration enhancers. Azone-like enhancers are considered in detail and classified according to their structure on the basis of medicinal chemistry approaches. The article also provides a review of original transdermal penetration enhancers prepared in our laboratory and discusses the relationship between the chemical structure of the described Azone analogues a

Název v anglickém jazyce

Azone Analogues: Classification, Design, and Transdermal Penetration Principles

Popis výsledku anglicky

The development in the field of pharmaceutical dosage forms results in the discovery of additional highly sophisticated drug delivery systems that allow maintaining a constant level of the active substance in an organism. Transdermal therapeutic systemsare an excellent alternative to conventional pharmaceutical dosage forms. However, the application of transdermal drug delivery faces the problem of insufficient or no penetration of active pharmaceutical substances through the skin. This review articledescribes the possible fundamental mechanisms of penetration through the skin barrier and refers to the classification of skin penetration enhancers. Azone-like enhancers are considered in detail and classified according to their structure on the basis of medicinal chemistry approaches. The article also provides a review of original transdermal penetration enhancers prepared in our laboratory and discusses the relationship between the chemical structure of the described Azone analogues a

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

—

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Medicinal research reviews

ISSN

0198-6325

e-ISSN

—

Svazek periodika

32

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

41

Strana od-do

907-947

Kód UT WoS článku

000307384100001

EID výsledku v databázi Scopus

—