Investigation of Carbohydrates and Their Derivatives as Crystallization Modifiers

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F12%3A43871550" target="_blank" >RIV/62157124:16370/12:43871550 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.5772/50626" target="_blank" >http://dx.doi.org/10.5772/50626</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5772/50626" target="_blank" >10.5772/50626</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Investigation of Carbohydrates and Their Derivatives as Crystallization Modifiers

Popis výsledku v původním jazyce

Twenty-eight carbohydrate derivatives were evaluated as formers during crystallization process of monosodium salts of alendronate, ibandronate and risedronate. All prepared samples were screened by FT-NIR and FT-Raman spectroscopy, and some new entitieswere checked by 31P and 13C CP/MAS NMR spectroscopy, XRPD and DSC. In the present study the relationships between the chemical structures of bisphosphonates and carbohydrates required for crystalline form change are investigated and discussed. It can beconcluded that in general carbohydrates can be used as crystallization modifiers, although none of carbohydrates afforded a new solid phase with alendronate. Ibandronate and risedronate generated new solid phases with phenyl-beta-D-galactopyranoside. Itis worth to note that both BPs IV and V contain trisubstituted nitrogen in contrast to alendronate (III), which can be an important factor that can cause different interactions. In case of BP IV it can be speculated about co-crystal gener

Název v anglickém jazyce

Investigation of Carbohydrates and Their Derivatives as Crystallization Modifiers

Popis výsledku anglicky

Twenty-eight carbohydrate derivatives were evaluated as formers during crystallization process of monosodium salts of alendronate, ibandronate and risedronate. All prepared samples were screened by FT-NIR and FT-Raman spectroscopy, and some new entitieswere checked by 31P and 13C CP/MAS NMR spectroscopy, XRPD and DSC. In the present study the relationships between the chemical structures of bisphosphonates and carbohydrates required for crystalline form change are investigated and discussed. It can beconcluded that in general carbohydrates can be used as crystallization modifiers, although none of carbohydrates afforded a new solid phase with alendronate. Ibandronate and risedronate generated new solid phases with phenyl-beta-D-galactopyranoside. Itis worth to note that both BPs IV and V contain trisubstituted nitrogen in contrast to alendronate (III), which can be an important factor that can cause different interactions. In case of BP IV it can be speculated about co-crystal gener

Druh

C - Kapitola v odborné knize

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/GAP304%2F11%2F2246" target="_blank" >GAP304/11/2246: Cílený transport léčiva přes biologické membrány</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Carbohydrates - Comprehensive Studies on Glycobiology and Glycotechnology

ISBN

978-953-51-0864-1

Počet stran výsledku

36

Strana od-do

81-116

Počet stran knihy

558

Název nakladatele

InTech

Místo vydání

Rijeka, Croatia

Kód UT WoS kapitoly

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