Use of Metabolomics for Monitoring Metabolic Responses Caused by Drug Administration 2. Application of Metabolomics in the Study of Metabolic Changes Induced by Drugs

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F12%3A43871553" target="_blank" >RIV/62157124:16370/12:43871553 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Use of Metabolomics for Monitoring Metabolic Responses Caused by Drug Administration 2. Application of Metabolomics in the Study of Metabolic Changes Induced by Drugs

Popis výsledku v původním jazyce

The aim of the paper is to present metabolomics as an effective tool for the study of responses of humans to drug treatment or animal models to drug administration. Generally, metabolomics can be used for monitoring disease status and drug efficacy, drugmetabolism, toxicity and drug-drug interactions. Attention is focused on different classes of drugs, and metabolite alterations caused by drug administration are analysed. Individual drugs are classified according to ATC groups. The selected drugs and pharmacotherapeutic groups were chosen according to their market share or potential. Antipsychotics, anti-inflammatory and antipyretic drugs, antihyperlipidemic agents, antiplatelet/anticoagulant drugs, antimicrobial chemotherapeutics, antineoplastic agents, immunosuppressants and contraceptives are discussed. In addition, the perspectives of the use of metabolomics for future drug discovery are outlined.

Název v anglickém jazyce

Use of Metabolomics for Monitoring Metabolic Responses Caused by Drug Administration 2. Application of Metabolomics in the Study of Metabolic Changes Induced by Drugs

Popis výsledku anglicky

The aim of the paper is to present metabolomics as an effective tool for the study of responses of humans to drug treatment or animal models to drug administration. Generally, metabolomics can be used for monitoring disease status and drug efficacy, drugmetabolism, toxicity and drug-drug interactions. Attention is focused on different classes of drugs, and metabolite alterations caused by drug administration are analysed. Individual drugs are classified according to ATC groups. The selected drugs and pharmacotherapeutic groups were chosen according to their market share or potential. Antipsychotics, anti-inflammatory and antipyretic drugs, antihyperlipidemic agents, antiplatelet/anticoagulant drugs, antimicrobial chemotherapeutics, antineoplastic agents, immunosuppressants and contraceptives are discussed. In addition, the perspectives of the use of metabolomics for future drug discovery are outlined.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Bulletion of Pharmaceutical Sciences

ISSN

1805-4161

e-ISSN

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Svazek periodika

1

Číslo periodika v rámci svazku

1-2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

13

Strana od-do

17-29

Kód UT WoS článku

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EID výsledku v databázi Scopus

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