Cationic Eudragit Polymers as Excipients for Microparticles Prepared by Solvent Evaporation Method

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F13%3A43872056" target="_blank" >RIV/62157124:16370/13:43872056 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Cationic Eudragit Polymers as Excipients for Microparticles Prepared by Solvent Evaporation Method

Popis výsledku v původním jazyce

Three cationic acrylic polymers, i. e. Eudragit RL, Eudragit RS and Eudragit E 100 were evaluated for the purpose of microparticles preparation by the solvent evaporation method. Practically insoluble drug mirtazapine and freely soluble drug tramadol hydrochloride were selected for encapsulation as extreme limits of drug solubility. Prepared microspheres were analyzed by optical microscopy, drug content analysis and dissolution test. It was observed that Eudragit RL did not provide microparticles whileEudragit RS and Eudragit E 100 gave spherical microparticles. Samples prepared with mirtazapine showed sustained drug release whereas tramadol hydrochloride samples released the drug in a pattern similar to immediate release profile. Eudragit RS was found to be superior to Eudragit E 100 in its encapsulation efficiency, drug loading and smaller mean size of microparticles.

Název v anglickém jazyce

Cationic Eudragit Polymers as Excipients for Microparticles Prepared by Solvent Evaporation Method

Popis výsledku anglicky

Three cationic acrylic polymers, i. e. Eudragit RL, Eudragit RS and Eudragit E 100 were evaluated for the purpose of microparticles preparation by the solvent evaporation method. Practically insoluble drug mirtazapine and freely soluble drug tramadol hydrochloride were selected for encapsulation as extreme limits of drug solubility. Prepared microspheres were analyzed by optical microscopy, drug content analysis and dissolution test. It was observed that Eudragit RL did not provide microparticles whileEudragit RS and Eudragit E 100 gave spherical microparticles. Samples prepared with mirtazapine showed sustained drug release whereas tramadol hydrochloride samples released the drug in a pattern similar to immediate release profile. Eudragit RS was found to be superior to Eudragit E 100 in its encapsulation efficiency, drug loading and smaller mean size of microparticles.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Česká a slovenská farmacie

ISSN

1210-7816

e-ISSN

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Svazek periodika

62

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

6

Strana od-do

249-254

Kód UT WoS článku

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EID výsledku v databázi Scopus

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