Olanzapine-depot administration induces time-dependent changes in adipose tissue endocrine function in rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F16%3A43874253" target="_blank" >RIV/62157124:16370/16:43874253 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/16:00090460

Výsledek na webu

<a href="http://ac.els-cdn.com/S0306453016304930/1-s2.0-S0306453016304930-main.pdf?_tid=49040a32-ee2c-11e6-a600-00000aab0f27&acdnat=1486578645_c2d40e8878865eb7e281b9af708205eb" target="_blank" >http://ac.els-cdn.com/S0306453016304930/1-s2.0-S0306453016304930-main.pdf?_tid=49040a32-ee2c-11e6-a600-00000aab0f27&acdnat=1486578645_c2d40e8878865eb7e281b9af708205eb</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.psyneuen.2016.07.218" target="_blank" >10.1016/j.psyneuen.2016.07.218</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Olanzapine-depot administration induces time-dependent changes in adipose tissue endocrine function in rats

Popis výsledku v původním jazyce

Objective: Metabolic adverse effects of atypical antipsychotics (AAP) contribute significantly to increasedrisk of cardiovascular morbidity and mortality in patients suffering from schizophrenia. Extensive preclin-ical research has addressed this issue over the past years, though mechanisms underlying these adverseeffects of AAP are still not understood completely. Recently, attention is drawn towards the role of adiposetissue metabolism and neurohormonal regulations. Methods: The aim of this study was to evaluate the time-dependent effects of olanzapine depot adminis-tration at clinically relevant dosing on the regulation of energy homeostasis, glucose and lipid metabolism,gastrointestinal and adipose tissue-derived hormones involved in energy balance regulations in female Sprague-Dawley rats. The study lasted 8 weeks and the markers were assayed at day 8, 15, 29, 43 and 57. Results: The results indicate that in the absence of hyperphagia, olanzapine chronic exposure inducedweight gain from the beginning of the study. In the later time-point, increased adiposity was alsoobserved. In the initial phase of the study, lipid profile was altered by an early increase in triglyceridelevel and highly elevated leptin level was observed. Clear bi-phasic time-dependent effect of olanzapineon leptin serum concentration was demonstrated. Olanzapine treatment did not lead to changes in serumlevels of ghrelin, FGF-21 and pro-inflammatory markers IL-1a, IL-6 and TNF-alpha at any time-point of thestudy. Conclusion: This study provides data suggesting early alteration in adipose tissue endocrine function asa factor involved in mechanisms underlying metabolic adverse effects of antipsychotics.

Název v anglickém jazyce

Olanzapine-depot administration induces time-dependent changes in adipose tissue endocrine function in rats

Popis výsledku anglicky

Objective: Metabolic adverse effects of atypical antipsychotics (AAP) contribute significantly to increasedrisk of cardiovascular morbidity and mortality in patients suffering from schizophrenia. Extensive preclin-ical research has addressed this issue over the past years, though mechanisms underlying these adverseeffects of AAP are still not understood completely. Recently, attention is drawn towards the role of adiposetissue metabolism and neurohormonal regulations. Methods: The aim of this study was to evaluate the time-dependent effects of olanzapine depot adminis-tration at clinically relevant dosing on the regulation of energy homeostasis, glucose and lipid metabolism,gastrointestinal and adipose tissue-derived hormones involved in energy balance regulations in female Sprague-Dawley rats. The study lasted 8 weeks and the markers were assayed at day 8, 15, 29, 43 and 57. Results: The results indicate that in the absence of hyperphagia, olanzapine chronic exposure inducedweight gain from the beginning of the study. In the later time-point, increased adiposity was alsoobserved. In the initial phase of the study, lipid profile was altered by an early increase in triglyceridelevel and highly elevated leptin level was observed. Clear bi-phasic time-dependent effect of olanzapineon leptin serum concentration was demonstrated. Olanzapine treatment did not lead to changes in serumlevels of ghrelin, FGF-21 and pro-inflammatory markers IL-1a, IL-6 and TNF-alpha at any time-point of thestudy. Conclusion: This study provides data suggesting early alteration in adipose tissue endocrine function asa factor involved in mechanisms underlying metabolic adverse effects of antipsychotics.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/LM2015090" target="_blank" >LM2015090: Český národní uzel Evropské sítě infrastruktur klinického výzkumu</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Psychoneuroendocrinology

ISSN

0306-4530

e-ISSN

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Svazek periodika

73

Číslo periodika v rámci svazku

November

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

177-185

Kód UT WoS článku

000385324800021

EID výsledku v databázi Scopus

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