Experimental Design for Determination of Effects of Superdisintegrant Combinations on Liquisolid System Properties

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F17%3A43875603" target="_blank" >RIV/62157124:16370/17:43875603 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11160/17:10364244

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.xphs.2016.11.002" target="_blank" >http://dx.doi.org/10.1016/j.xphs.2016.11.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.xphs.2016.11.002" target="_blank" >10.1016/j.xphs.2016.11.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Experimental Design for Determination of Effects of Superdisintegrant Combinations on Liquisolid System Properties

Popis výsledku v původním jazyce

The preparation of liquisolid systems presents a promising and innovative possibility for enhancing dissolution profiles and improving the bioavailability of poorly soluble drugs. This study aims to evaluate the differences in the properties of liquisolid systems containing combinations of 3 commercially used superdisintegrants (sodium starch glycolate, crospovidone, and croscarmellose sodium). Multiple regression models and contour plots were used to study how the amount and the type of superdisintegrant used affected the quality parameters of liquisolid tablets. The results revealed that an increased amount of crospovidone in the mixture improves disintegration and wetting time and enhances drug release from the prepared liquisolid tablets. Moreover, it was observed that a binary blend of crospovidone and sodium starch glycolate improved tablet disintegration. Considering the obtained results, it could be stated that crospovidone showed the best properties to be used as superdisintegrant for the preparation of liquisolid systems containing rosuvastatin.

Název v anglickém jazyce

Experimental Design for Determination of Effects of Superdisintegrant Combinations on Liquisolid System Properties

Popis výsledku anglicky

The preparation of liquisolid systems presents a promising and innovative possibility for enhancing dissolution profiles and improving the bioavailability of poorly soluble drugs. This study aims to evaluate the differences in the properties of liquisolid systems containing combinations of 3 commercially used superdisintegrants (sodium starch glycolate, crospovidone, and croscarmellose sodium). Multiple regression models and contour plots were used to study how the amount and the type of superdisintegrant used affected the quality parameters of liquisolid tablets. The results revealed that an increased amount of crospovidone in the mixture improves disintegration and wetting time and enhances drug release from the prepared liquisolid tablets. Moreover, it was observed that a binary blend of crospovidone and sodium starch glycolate improved tablet disintegration. Considering the obtained results, it could be stated that crospovidone showed the best properties to be used as superdisintegrant for the preparation of liquisolid systems containing rosuvastatin.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Pharmaceutical sciences

ISSN

0022-3549

e-ISSN

—

Svazek periodika

106

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

817-825

Kód UT WoS článku

000400398400016

EID výsledku v databázi Scopus

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