Atherogenic index of plasma is positively associated with the risk of all-cause death in elderly women A 10-year follow-up
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F17%3A43875999" target="_blank" >RIV/62157124:16370/17:43875999 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216224:14110/17:00098763 RIV/00159816:_____/17:00067715
Výsledek na webu
<a href="http://dx.doi.org/10.1007/s00508-017-1264-1" target="_blank" >http://dx.doi.org/10.1007/s00508-017-1264-1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00508-017-1264-1" target="_blank" >10.1007/s00508-017-1264-1</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Atherogenic index of plasma is positively associated with the risk of all-cause death in elderly women A 10-year follow-up
Popis výsledku v původním jazyce
Background The blood concentrations of total cholesterol and low-density lipoprotein (LDL) do not predict survival in patients older than 60 years. The atherogenic index of plasma (AIP) is a logarithm of the triacylglycerol to high-density lipoprotein (HDL) ratio and a surrogate for the concentration of small dense LDL. It might be a better reflection of the risk of all-cause death in elderly patients. Methods We conducted a prospective observational study of patients with arterial hypertension older than 60 years. The concentrations of total cholesterol, LDL, HDL and triacylglycerol were measured at the time of the recruitment and the patients were observed for 10 years. Cox regression analysis was performed to assess the effects of lipoproteins and AIP on survival. Results A total of 500 patients were recruited and 473 of them (226 men, 247 women) either died or successfully completed the 10-year follow-up and were included in the analysis. The AIP was positively associated, while HDL concentration was negatively associated with the risk of all-cause death adjusted for age, smoking habits, statin use, history of diabetes mellitus, myocardial infarction, stroke and peripheral artery occlusive disease (PAOD) in elderly women but not in men. The LDL, total cholesterol, triacylglycerol and non-HDL concentrations were not associated with the risk of death in both sexes. Conclusions The AIP is positively associated with the risk of all-cause death in elderly women with arterial hypertension independent of age, smoking habits, statin therapy and comorbidities.
Název v anglickém jazyce
Atherogenic index of plasma is positively associated with the risk of all-cause death in elderly women A 10-year follow-up
Popis výsledku anglicky
Background The blood concentrations of total cholesterol and low-density lipoprotein (LDL) do not predict survival in patients older than 60 years. The atherogenic index of plasma (AIP) is a logarithm of the triacylglycerol to high-density lipoprotein (HDL) ratio and a surrogate for the concentration of small dense LDL. It might be a better reflection of the risk of all-cause death in elderly patients. Methods We conducted a prospective observational study of patients with arterial hypertension older than 60 years. The concentrations of total cholesterol, LDL, HDL and triacylglycerol were measured at the time of the recruitment and the patients were observed for 10 years. Cox regression analysis was performed to assess the effects of lipoproteins and AIP on survival. Results A total of 500 patients were recruited and 473 of them (226 men, 247 women) either died or successfully completed the 10-year follow-up and were included in the analysis. The AIP was positively associated, while HDL concentration was negatively associated with the risk of all-cause death adjusted for age, smoking habits, statin use, history of diabetes mellitus, myocardial infarction, stroke and peripheral artery occlusive disease (PAOD) in elderly women but not in men. The LDL, total cholesterol, triacylglycerol and non-HDL concentrations were not associated with the risk of death in both sexes. Conclusions The AIP is positively associated with the risk of all-cause death in elderly women with arterial hypertension independent of age, smoking habits, statin therapy and comorbidities.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30104 - Pharmacology and pharmacy
Návaznosti výsledku
Projekt
—
Návaznosti
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Ostatní
Rok uplatnění
2017
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Wiener Klinische Wochenschrift
ISSN
0043-5325
e-ISSN
—
Svazek periodika
129
Číslo periodika v rámci svazku
21-22
Stát vydavatele periodika
AT - Rakouská republika
Počet stran výsledku
6
Strana od-do
793-798
Kód UT WoS článku
000414784300003
EID výsledku v databázi Scopus
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