Inducible nitric oxide synthase: Good or bad?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F17%3A43876003" target="_blank" >RIV/62157124:16370/17:43876003 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/17:00099908 RIV/00159816:_____/17:00068027

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.biopha.2017.06.036" target="_blank" >http://dx.doi.org/10.1016/j.biopha.2017.06.036</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.biopha.2017.06.036" target="_blank" >10.1016/j.biopha.2017.06.036</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Inducible nitric oxide synthase: Good or bad?

Popis výsledku v původním jazyce

Nitric oxide synthases (NOS) are a family of isoforms responsible for the synthesis of the potent dilator nitric oxide (NO). Expression of inducible NOS (iNOS) occurs in conditions of inflammation, and produces large amounts of NO. In pathological conditions iNOS is regarded as a harmful enzyme and is proposed to be a major contributor to diseases of the cardiovascular system such as atherosclerosis. In this review, we address the notion that iNOS is a detrimental enzyme in disease and discuss its potentially beneficial roles. Additionally, we describe other molecules associated with iNOS in diseases such as atherosclerosis, and current research on therapeutic inhibitors tested to reduced pathology associated with cardiovascular diseases (CVD).

Název v anglickém jazyce

Inducible nitric oxide synthase: Good or bad?

Popis výsledku anglicky

Nitric oxide synthases (NOS) are a family of isoforms responsible for the synthesis of the potent dilator nitric oxide (NO). Expression of inducible NOS (iNOS) occurs in conditions of inflammation, and produces large amounts of NO. In pathological conditions iNOS is regarded as a harmful enzyme and is proposed to be a major contributor to diseases of the cardiovascular system such as atherosclerosis. In this review, we address the notion that iNOS is a detrimental enzyme in disease and discuss its potentially beneficial roles. Additionally, we describe other molecules associated with iNOS in diseases such as atherosclerosis, and current research on therapeutic inhibitors tested to reduced pathology associated with cardiovascular diseases (CVD).

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedicine &amp; pharmacotherapy

ISSN

0753-3322

e-ISSN

—

Svazek periodika

93

Číslo periodika v rámci svazku

SEP 2017

Stát vydavatele periodika

FR - Francouzská republika

Počet stran výsledku

6

Strana od-do

370-375

Kód UT WoS článku

000407923000040

EID výsledku v databázi Scopus

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