Association of serum levels of anti-myeloperoxidase antibody with retinal photoreceptor ellipsoid zone disruption in diabetic retinopathy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F17%3A43876012" target="_blank" >RIV/62157124:16370/17:43876012 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.jdiacomp.2017.02.011" target="_blank" >http://dx.doi.org/10.1016/j.jdiacomp.2017.02.011</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jdiacomp.2017.02.011" target="_blank" >10.1016/j.jdiacomp.2017.02.011</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Association of serum levels of anti-myeloperoxidase antibody with retinal photoreceptor ellipsoid zone disruption in diabetic retinopathy

Popis výsledku v původním jazyce

Aim: To study the association of serum levels of anti-myeloperoxidase (MPO) antibody with retinal photoreceptor ellipsoid zone (EZ) disruption in diabetic retinopathy. Methods: Consecutive patients with type 2 DM [diabetes mellitus with no retinopathy (NODR; n = 20); non-proliferative diabetic retinopathy (NPDR; n = 18); proliferative diabetic retinopathy (PDR; n = 16)] and healthy controls (n = 20) between the ages of 40 and 65 years were included. Disruption of EZ was graded by spectral domain optical coherence tomography as no disruption of EZ and disrupted EZ The serum levels of anti-MPO antibody was analyzed using standard protocol. Association between the variables was evaluated using multiple regression analysis. Results: A significant difference was found between the serum levels of anti-MPO antibody in various study groups (p &lt; 0.001). A positive association was found between EZ disruption and levels of anti-MPO antibody [adjusted odd&apos;s ratio (AOR) = 1.079, CI 1.010-1124, p = 0.04]. A significant positive correlation was found between logMAR, visual acuity and grade of disruption (AOR = 1.008, CI 1.006-5.688, p = 0.04). Conclusions: An increased serum anti-MPO antibody levels is associated with retinal photoreceptor EZ disruption and decreased visual acuity in diabetic retinopathy.

Název v anglickém jazyce

Association of serum levels of anti-myeloperoxidase antibody with retinal photoreceptor ellipsoid zone disruption in diabetic retinopathy

Popis výsledku anglicky

Aim: To study the association of serum levels of anti-myeloperoxidase (MPO) antibody with retinal photoreceptor ellipsoid zone (EZ) disruption in diabetic retinopathy. Methods: Consecutive patients with type 2 DM [diabetes mellitus with no retinopathy (NODR; n = 20); non-proliferative diabetic retinopathy (NPDR; n = 18); proliferative diabetic retinopathy (PDR; n = 16)] and healthy controls (n = 20) between the ages of 40 and 65 years were included. Disruption of EZ was graded by spectral domain optical coherence tomography as no disruption of EZ and disrupted EZ The serum levels of anti-MPO antibody was analyzed using standard protocol. Association between the variables was evaluated using multiple regression analysis. Results: A significant difference was found between the serum levels of anti-MPO antibody in various study groups (p &lt; 0.001). A positive association was found between EZ disruption and levels of anti-MPO antibody [adjusted odd&apos;s ratio (AOR) = 1.079, CI 1.010-1124, p = 0.04]. A significant positive correlation was found between logMAR, visual acuity and grade of disruption (AOR = 1.008, CI 1.006-5.688, p = 0.04). Conclusions: An increased serum anti-MPO antibody levels is associated with retinal photoreceptor EZ disruption and decreased visual acuity in diabetic retinopathy.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of diabetes and its complications

ISSN

1056-8727

e-ISSN

—

Svazek periodika

31

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

864-868

Kód UT WoS článku

000401683600015

EID výsledku v databázi Scopus

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