Perspectives and challenges of antioxidant therapy for atrial fibrillation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F17%3A43876022" target="_blank" >RIV/62157124:16370/17:43876022 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/17:00098629

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s00210-016-1320-9" target="_blank" >http://dx.doi.org/10.1007/s00210-016-1320-9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00210-016-1320-9" target="_blank" >10.1007/s00210-016-1320-9</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Perspectives and challenges of antioxidant therapy for atrial fibrillation

Popis výsledku v původním jazyce

Atrial fibrillation (AF) is the most common sustained arrhythmia associated with significant morbidity and mortality. The mechanisms underlying the pathogenesis of AF are poorly understood, although electrophysiological remodeling has been described as an important initiating step. There is growing evidence that oxidative stress is involved in the pathogenesis of AF. Many known triggers of oxidative stress, such as age, diabetes, smoking, and inflammation, are linked with an increased risk of arrhythmia. Numerous preclinical studies and clinical trials reported the importance of antioxidant therapy in the prevention of AF, using vitamins C and E, polyunsaturated fatty acids, statins, or nitric oxide donors. The aim of our work is to give a current overview and analysis of opportunities, challenges, and benefits of antioxidant therapy in AF.

Název v anglickém jazyce

Perspectives and challenges of antioxidant therapy for atrial fibrillation

Popis výsledku anglicky

Atrial fibrillation (AF) is the most common sustained arrhythmia associated with significant morbidity and mortality. The mechanisms underlying the pathogenesis of AF are poorly understood, although electrophysiological remodeling has been described as an important initiating step. There is growing evidence that oxidative stress is involved in the pathogenesis of AF. Many known triggers of oxidative stress, such as age, diabetes, smoking, and inflammation, are linked with an increased risk of arrhythmia. Numerous preclinical studies and clinical trials reported the importance of antioxidant therapy in the prevention of AF, using vitamins C and E, polyunsaturated fatty acids, statins, or nitric oxide donors. The aim of our work is to give a current overview and analysis of opportunities, challenges, and benefits of antioxidant therapy in AF.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Naunyn-schmiedebergs archives of pharmacology

ISSN

0028-1298

e-ISSN

—

Svazek periodika

390

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

14

Strana od-do

1-14

Kód UT WoS článku

000391361200001

EID výsledku v databázi Scopus

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