Development of Orodispersible Films Containing Benzydamine Hydrochloride Using a Modified Solvent Casting Method

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F18%3A43876652" target="_blank" >RIV/62157124:16370/18:43876652 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1208/s12249-018-1088-y" target="_blank" >http://dx.doi.org/10.1208/s12249-018-1088-y</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1208/s12249-018-1088-y" target="_blank" >10.1208/s12249-018-1088-y</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Development of Orodispersible Films Containing Benzydamine Hydrochloride Using a Modified Solvent Casting Method

Popis výsledku v původním jazyce

The aim of this study was to develop benzydamine hydrochloride-loaded orodispersible films using the modification of a solvent casting method. An innovative approach was developed when the drying process of a small-scale production was used based on a heated inert base for casting the film. During this process, two types of film-forming maltodextrins for rapid drug delivery were used. They were plasticized with two different polyols (xylitol and sorbitol). Superdisintegrant KollidonA (R) CL-F was tested as an excipient that can induce faster disintegration of the prepared films. The influence of the formulation parameters (dextrose equivalent of film-forming maltodextrins, a type of plasticizer, and the presence of superdisintegrant) on the disintegration time, mechanical properties, and moisture content of films was statistically evaluated using a multivariate data analysis. Orodispersible films containing maltodextrin with lower dextrose equivalent value showed better mechanical properties (tensile strength ranged from 886.6 +/- 30.2 to 1484.2 +/- 226.9 N cm(-2)), lower moisture content (0.5 +/- 0.0 to 1.2 +/- 0.2%), and shorter disintegration time (17.6 +/- 2.9 to 27.8 +/- 2.8 s). Films plasticized with xylitol showed shorter disintegration time (17.6 +/- 2.9 to 29.2 +/- 3.8 s) than films containing sorbitol (23.8 +/- 2.9 to 31.7 +/- 3.9 s). With the addition of superdisintegrant KollidonA (R) CL-F, a significant influence on disintegration time was not observed. The modified solvent casting method shows great promise in a small-scale laboratory production of orodispersible films, e.g., in a pharmacy lab.

Název v anglickém jazyce

Development of Orodispersible Films Containing Benzydamine Hydrochloride Using a Modified Solvent Casting Method

Popis výsledku anglicky

The aim of this study was to develop benzydamine hydrochloride-loaded orodispersible films using the modification of a solvent casting method. An innovative approach was developed when the drying process of a small-scale production was used based on a heated inert base for casting the film. During this process, two types of film-forming maltodextrins for rapid drug delivery were used. They were plasticized with two different polyols (xylitol and sorbitol). Superdisintegrant KollidonA (R) CL-F was tested as an excipient that can induce faster disintegration of the prepared films. The influence of the formulation parameters (dextrose equivalent of film-forming maltodextrins, a type of plasticizer, and the presence of superdisintegrant) on the disintegration time, mechanical properties, and moisture content of films was statistically evaluated using a multivariate data analysis. Orodispersible films containing maltodextrin with lower dextrose equivalent value showed better mechanical properties (tensile strength ranged from 886.6 +/- 30.2 to 1484.2 +/- 226.9 N cm(-2)), lower moisture content (0.5 +/- 0.0 to 1.2 +/- 0.2%), and shorter disintegration time (17.6 +/- 2.9 to 27.8 +/- 2.8 s). Films plasticized with xylitol showed shorter disintegration time (17.6 +/- 2.9 to 29.2 +/- 3.8 s) than films containing sorbitol (23.8 +/- 2.9 to 31.7 +/- 3.9 s). With the addition of superdisintegrant KollidonA (R) CL-F, a significant influence on disintegration time was not observed. The modified solvent casting method shows great promise in a small-scale laboratory production of orodispersible films, e.g., in a pharmacy lab.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

AAPS PharmSciTech

ISSN

1530-9932

e-ISSN

—

Svazek periodika

19

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

2509-2518

Kód UT WoS článku

000440308000007

EID výsledku v databázi Scopus

2-s2.0-85048369928