Effect of liquid vehicles on the enhancement of rosmarinic acid and carvacrol release from oregano extract liquisolid compacts

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F18%3A43876659" target="_blank" >RIV/62157124:16370/18:43876659 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.colsurfa.2017.12.034" target="_blank" >http://dx.doi.org/10.1016/j.colsurfa.2017.12.034</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.colsurfa.2017.12.034" target="_blank" >10.1016/j.colsurfa.2017.12.034</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effect of liquid vehicles on the enhancement of rosmarinic acid and carvacrol release from oregano extract liquisolid compacts

Popis výsledku v původním jazyce

Spraying and freeze-drying of various herbal extracts is often used for industrial dry herbal powder preparation. However, it is possible to produce a better quality powder applying liquisolid compact technique with the simpler preparation process. The aim of this study was to evaluate the influence of liquisolid and freeze-drying techniques on physicochemical properties of Oregano powder and the yield of its active compounds-rosmarinic acid and carvacrol. The quantities of active compounds were determined by UPLC method. The accelerated and long-term stability studies of all formulations have also been evaluated. The physicochemical characteristics and the morphology of the dry powder were evaluated using X-ray diffraction, UPLC-ESI-MS and scanning electron microscopy. The results showed that Oregano powder obtained by freeze-drying was hygroscopic and showed passable flow properties, with the angle of repose 43.00 +/- 0.87 degrees and flowability 0 g/s. The X-ray diffraction method showed amorphous state of the active ingredients in the liquisolid formulations. Furthermore, the dissolution tests in vitro confirmed that liquisolid systems released 2.2-2.8-fold more rosmarinic acid and 2.9-fold more carvacrol compared to the Oregano powder obtained by freeze-drying (p &lt; .05). The stability studies showed that physicomechanical properties, the dissolution profiles, rosmarinic acid and carvacrol content of liquisolid formulations were not significantly affected by ageing. In conclusion, the use of liquisolid compacts could be a promising tool to increase the solubility of Oregano extract active compounds. The liquisolid technology is especially promising for herbal drugs preparation because of the simple manufacturing process, low production costs and the possibility of industrial manufacture due to the good flow and compaction properties, and the ability to protect the active compounds from oxidation.

Název v anglickém jazyce

Effect of liquid vehicles on the enhancement of rosmarinic acid and carvacrol release from oregano extract liquisolid compacts

Popis výsledku anglicky

Spraying and freeze-drying of various herbal extracts is often used for industrial dry herbal powder preparation. However, it is possible to produce a better quality powder applying liquisolid compact technique with the simpler preparation process. The aim of this study was to evaluate the influence of liquisolid and freeze-drying techniques on physicochemical properties of Oregano powder and the yield of its active compounds-rosmarinic acid and carvacrol. The quantities of active compounds were determined by UPLC method. The accelerated and long-term stability studies of all formulations have also been evaluated. The physicochemical characteristics and the morphology of the dry powder were evaluated using X-ray diffraction, UPLC-ESI-MS and scanning electron microscopy. The results showed that Oregano powder obtained by freeze-drying was hygroscopic and showed passable flow properties, with the angle of repose 43.00 +/- 0.87 degrees and flowability 0 g/s. The X-ray diffraction method showed amorphous state of the active ingredients in the liquisolid formulations. Furthermore, the dissolution tests in vitro confirmed that liquisolid systems released 2.2-2.8-fold more rosmarinic acid and 2.9-fold more carvacrol compared to the Oregano powder obtained by freeze-drying (p &lt; .05). The stability studies showed that physicomechanical properties, the dissolution profiles, rosmarinic acid and carvacrol content of liquisolid formulations were not significantly affected by ageing. In conclusion, the use of liquisolid compacts could be a promising tool to increase the solubility of Oregano extract active compounds. The liquisolid technology is especially promising for herbal drugs preparation because of the simple manufacturing process, low production costs and the possibility of industrial manufacture due to the good flow and compaction properties, and the ability to protect the active compounds from oxidation.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Colloids and surfaces a-physicochemical and engineering aspects

ISSN

0927-7757

e-ISSN

—

Svazek periodika

539

Číslo periodika v rámci svazku

20

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

11

Strana od-do

280-290

Kód UT WoS článku

000424953600034

EID výsledku v databázi Scopus

2-s2.0-85038809824