INFLUENCE OF NEWLY DEVELOPED HEMOSTATIC AGENTS ON THE INFLAMMATION RESPONSE IN TRAUMATICALLY INJURED KIDNEY

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

INFLUENCE OF NEWLY DEVELOPED HEMOSTATIC AGENTS ON THE INFLAMMATION RESPONSE IN TRAUMATICALLY INJURED KIDNEY

Popis výsledku v původním jazyce

Various surgical procedures require application of an effective hemostatic material. Appropriate agent should prove high hemostatic activity and besides also biocompatibility and potential bioresorbability. The aim of this study was evaluation of the local tissue reaction in rat?s kidney after surgical intervention and application of hemostatic textiles. We used a common model of partial nephrectomy. We assessed new cellulose nonwoven textiles based on oxidized cellulose and sodium salt of carboxymethylcellulose in comparison with a fibrilar form of regenerated oxidized cellulose. Materials were attached to the wound to effectively stop the bleeding and left in the same location while the peritoneum was sutured. Main purpose was to investigate the influence on the renal parenchyma after 3 and 30 days from the surgery. We leaned on the results from renal histology and immunohistochemistry considering histological changes and kidney cytokines TNF-?, TGF-? as inflammation markers. Obtained results revealed better hemostatic activity of the new carboxymethylcellulose material together with beneficial effect on the healing tissue.

Název v anglickém jazyce

INFLUENCE OF NEWLY DEVELOPED HEMOSTATIC AGENTS ON THE INFLAMMATION RESPONSE IN TRAUMATICALLY INJURED KIDNEY

Popis výsledku anglicky

Various surgical procedures require application of an effective hemostatic material. Appropriate agent should prove high hemostatic activity and besides also biocompatibility and potential bioresorbability. The aim of this study was evaluation of the local tissue reaction in rat?s kidney after surgical intervention and application of hemostatic textiles. We used a common model of partial nephrectomy. We assessed new cellulose nonwoven textiles based on oxidized cellulose and sodium salt of carboxymethylcellulose in comparison with a fibrilar form of regenerated oxidized cellulose. Materials were attached to the wound to effectively stop the bleeding and left in the same location while the peritoneum was sutured. Main purpose was to investigate the influence on the renal parenchyma after 3 and 30 days from the surgery. We leaned on the results from renal histology and immunohistochemistry considering histological changes and kidney cytokines TNF-?, TGF-? as inflammation markers. Obtained results revealed better hemostatic activity of the new carboxymethylcellulose material together with beneficial effect on the healing tissue.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30108 - Toxicology

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů