Genetic association of single nucleotide polymorphisms of FZD4 and BDNF genes with retinopathy of prematurity
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F18%3A43877068" target="_blank" >RIV/62157124:16370/18:43877068 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1080/13816810.2018.1432064" target="_blank" >http://dx.doi.org/10.1080/13816810.2018.1432064</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/13816810.2018.1432064" target="_blank" >10.1080/13816810.2018.1432064</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Genetic association of single nucleotide polymorphisms of FZD4 and BDNF genes with retinopathy of prematurity
Popis výsledku v původním jazyce
Background: Retinopathy of prematurity (ROP) is a multifactorial disease occurring in preterm neonates, caused by incorrect development of retinal blood vessels. It has been suggested that, in addition to gestational age, weight, and oxygen supplementation, genetic factors can play a role in the pathogenesis of ROP. Methods: In the present prospective study, 97 neonates were enrolled based on the gestational age and weight, and genomic DNA from patients diagnosed with ROP and premature newborns without ROP was collected. The DNA sequence of protein coding and 5' and 3' untranslated regions (UTRs) of the frizzled-4 (FZD4) gene and the genotype of the locus rs7934165:G > A (NM_170731.4: c.3+10976 C > T) within the brain-derived neurotrophic factor gene (BDNF) were determined. Results: We detected a significant association between rs61749246:C > A (NM_012193.3: c.*2G > T) and ROP in a general genetic model as well as in a multiplicative model and by the Cochran-Armitage test for trend. Moreover, rs61749246 was strongly associated with ROP, requiring surgical intervention. Conclusion: We suggest that rs61749246:C > A of the FZD4 gene is likely associated with the development of ROP. It is necessary to confirm this suggestion in larger studies.
Název v anglickém jazyce
Genetic association of single nucleotide polymorphisms of FZD4 and BDNF genes with retinopathy of prematurity
Popis výsledku anglicky
Background: Retinopathy of prematurity (ROP) is a multifactorial disease occurring in preterm neonates, caused by incorrect development of retinal blood vessels. It has been suggested that, in addition to gestational age, weight, and oxygen supplementation, genetic factors can play a role in the pathogenesis of ROP. Methods: In the present prospective study, 97 neonates were enrolled based on the gestational age and weight, and genomic DNA from patients diagnosed with ROP and premature newborns without ROP was collected. The DNA sequence of protein coding and 5' and 3' untranslated regions (UTRs) of the frizzled-4 (FZD4) gene and the genotype of the locus rs7934165:G > A (NM_170731.4: c.3+10976 C > T) within the brain-derived neurotrophic factor gene (BDNF) were determined. Results: We detected a significant association between rs61749246:C > A (NM_012193.3: c.*2G > T) and ROP in a general genetic model as well as in a multiplicative model and by the Cochran-Armitage test for trend. Moreover, rs61749246 was strongly associated with ROP, requiring surgical intervention. Conclusion: We suggest that rs61749246:C > A of the FZD4 gene is likely associated with the development of ROP. It is necessary to confirm this suggestion in larger studies.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30107 - Medicinal chemistry
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2018
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Ophthalmic Genetics
ISSN
1381-6810
e-ISSN
—
Svazek periodika
39
Číslo periodika v rámci svazku
3
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
6
Strana od-do
332-337
Kód UT WoS článku
000430504100007
EID výsledku v databázi Scopus
2-s2.0-85042218984