Investigation of Permeation of Acyclovir through Skin Using Alaptide

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F18%3A43877069" target="_blank" >RIV/62157124:16370/18:43877069 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68081715:_____/18:00478814

Výsledek na webu

<a href="http://dx.doi.org/10.1556/1326.2017.00242" target="_blank" >http://dx.doi.org/10.1556/1326.2017.00242</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1556/1326.2017.00242" target="_blank" >10.1556/1326.2017.00242</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Investigation of Permeation of Acyclovir through Skin Using Alaptide

Popis výsledku v původním jazyce

The investigation deals with the affection of the permeation of acyclovir through full-thickness pig ear skin using a Franz diffusion cell from the donor vehicles of phosphate buffer (pH 7.4) and propylene glycol-water (1: 1) using synthesised (S)-8-methyl-6,9-diazaspiro[4.5] decane-7,10-dione, alaptide as a transdermal permeation enhancer. Alaptide was applied in ratio 1:10 (w/w) relative to the amount of acyclovir. At the first hour after application, the permeated amount of acyclovir from propylene glycol-water system, simulating semisolid dosage forms, was ca. four-fold higher than from the formulation without alaptide. Despite that the enhancement ratio of alaptide in a steady state was 1.7, the pseudo-enhancement ratio of alaptide in the time range of first to third hour was 2.3. Both enhancement ratios indicate that alaptide modifies skin structure, while the short-term application of the alaptide formulation seems to be more advantageous.

Název v anglickém jazyce

Investigation of Permeation of Acyclovir through Skin Using Alaptide

Popis výsledku anglicky

The investigation deals with the affection of the permeation of acyclovir through full-thickness pig ear skin using a Franz diffusion cell from the donor vehicles of phosphate buffer (pH 7.4) and propylene glycol-water (1: 1) using synthesised (S)-8-methyl-6,9-diazaspiro[4.5] decane-7,10-dione, alaptide as a transdermal permeation enhancer. Alaptide was applied in ratio 1:10 (w/w) relative to the amount of acyclovir. At the first hour after application, the permeated amount of acyclovir from propylene glycol-water system, simulating semisolid dosage forms, was ca. four-fold higher than from the formulation without alaptide. Despite that the enhancement ratio of alaptide in a steady state was 1.7, the pseudo-enhancement ratio of alaptide in the time range of first to third hour was 2.3. Both enhancement ratios indicate that alaptide modifies skin structure, while the short-term application of the alaptide formulation seems to be more advantageous.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30107 - Medicinal chemistry

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta chromatographica

ISSN

1233-2356

e-ISSN

—

Svazek periodika

30

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

HU - Maďarsko

Počet stran výsledku

4

Strana od-do

62-65

Kód UT WoS článku

000428083500011

EID výsledku v databázi Scopus

2-s2.0-85045944718