Antitussive activity of alcoxyphenyl carbamic acid analogues

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F18%3A43877071" target="_blank" >RIV/62157124:16370/18:43877071 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.4149/gpb_2017048" target="_blank" >http://dx.doi.org/10.4149/gpb_2017048</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/gpb_2017048" target="_blank" >10.4149/gpb_2017048</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Antitussive activity of alcoxyphenyl carbamic acid analogues

Popis výsledku v původním jazyce

In this study we report pharmacological evaluation of four newly synthetized analogues of alcoxyphenyl carbamic acid, structurally related to butamirate citrate that is frequently used as cough suppressing drug, and marked as ATK 231, ATK 241, ATK 251 and ATK 261. These agents with various modifications of the molecular structure have been tested for antitussive activity in cough induced by inhalation of aerosol of citric acid (0.3 M) over 3 minutes using conscious guinea pigs. Results revealed significant cough suppressing activity without significant influence on specific airways resistances in all tested substances. ATK 231 and ATK241 showed significantly higher total antitussive activities when compared to both codeine phosphate and butamirate citrate, while ATK 251 only comparing to butamirate citrate. We did not observe any notable adverse effects and these compounds could thus potentially represent promising new non -narcotic antitussives suitable for further studies.

Název v anglickém jazyce

Antitussive activity of alcoxyphenyl carbamic acid analogues

Popis výsledku anglicky

In this study we report pharmacological evaluation of four newly synthetized analogues of alcoxyphenyl carbamic acid, structurally related to butamirate citrate that is frequently used as cough suppressing drug, and marked as ATK 231, ATK 241, ATK 251 and ATK 261. These agents with various modifications of the molecular structure have been tested for antitussive activity in cough induced by inhalation of aerosol of citric acid (0.3 M) over 3 minutes using conscious guinea pigs. Results revealed significant cough suppressing activity without significant influence on specific airways resistances in all tested substances. ATK 231 and ATK241 showed significantly higher total antitussive activities when compared to both codeine phosphate and butamirate citrate, while ATK 251 only comparing to butamirate citrate. We did not observe any notable adverse effects and these compounds could thus potentially represent promising new non -narcotic antitussives suitable for further studies.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30107 - Medicinal chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

General physiology and biophysics

ISSN

0231-5882

e-ISSN

—

Svazek periodika

37

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

7

Strana od-do

337-343

Kód UT WoS článku

000435065400010

EID výsledku v databázi Scopus

2-s2.0-85048512426