The metabolic profile of essential oils and assessment of anti-urease activity by ESI-mass spectrometry of Salvia officinalis L.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F19%3A43877430" target="_blank" >RIV/62157124:16370/19:43877430 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0254629918300796" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0254629918300796</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.sajb.2018.04.023" target="_blank" >10.1016/j.sajb.2018.04.023</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The metabolic profile of essential oils and assessment of anti-urease activity by ESI-mass spectrometry of Salvia officinalis L.

Popis výsledku v původním jazyce

For decades, the therapeutic benefits of medicinal plants and their biologically active constituents have been well documented. In this study, the metabolic profile of Egyptian Salvia officinalis essential oils using Gas Chromatography (GC) and Gas Chromatography-Mass Spectrometry (GC-MS), total phenolic content (TPC) and anti-enzymatic properties of aqueous extract of S. officinalis (AESO) against jack bean urease (JBU) by an Electrospray Ionization-Mass Spectrometry (ESI-MS) were investigated. The results revealed that the primary metabolites detected in Salvia essential oils were 1,8-cineole (15.4%), oxygenated sesquiterpene viridiflorol (7.1%), nonacosane (3.1%), camphor (3.0%), and pentacosane (2.4%). The TPC content was determined to be 37.1 mg GAE/g dry plant material, while AESO exerted for the first time, anti-JBU with an IC50 value of 1.65 mg/mL. This study presents phenolic-rich AESO as a promising curative agent in the development of urease inhibitors useful to treat diseases induced by urease-producing pathogens.

Název v anglickém jazyce

The metabolic profile of essential oils and assessment of anti-urease activity by ESI-mass spectrometry of Salvia officinalis L.

Popis výsledku anglicky

For decades, the therapeutic benefits of medicinal plants and their biologically active constituents have been well documented. In this study, the metabolic profile of Egyptian Salvia officinalis essential oils using Gas Chromatography (GC) and Gas Chromatography-Mass Spectrometry (GC-MS), total phenolic content (TPC) and anti-enzymatic properties of aqueous extract of S. officinalis (AESO) against jack bean urease (JBU) by an Electrospray Ionization-Mass Spectrometry (ESI-MS) were investigated. The results revealed that the primary metabolites detected in Salvia essential oils were 1,8-cineole (15.4%), oxygenated sesquiterpene viridiflorol (7.1%), nonacosane (3.1%), camphor (3.0%), and pentacosane (2.4%). The TPC content was determined to be 37.1 mg GAE/g dry plant material, while AESO exerted for the first time, anti-JBU with an IC50 value of 1.65 mg/mL. This study presents phenolic-rich AESO as a promising curative agent in the development of urease inhibitors useful to treat diseases induced by urease-producing pathogens.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10611 - Plant sciences, botany

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

South African Journal of Botany

ISSN

0254-6299

e-ISSN

—

Svazek periodika

120

Číslo periodika v rámci svazku

Jan

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

4

Strana od-do

175-178

Kód UT WoS článku

000456314600022

EID výsledku v databázi Scopus

2-s2.0-85047202626