MRI findings induced by antipsychotic treatment and animal models of schizophrenia-like pathology

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F19%3A43877922" target="_blank" >RIV/62157124:16370/19:43877922 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

MRI findings induced by antipsychotic treatment and animal models of schizophrenia-like pathology

Popis výsledku v původním jazyce

Schizophrenia (SCZ) is a debilitating mental illness resulting in multiple structural and functional brain changes. We used Arterial Spin Labelling MRI technique in all studies to evaluate cerebral blood perfusion in SCZ-related brain regions using Bruker BioSpec 94/30 scanner. Study 1 was focused on the effect of acute and chronic olanzapine exposure. The aim of Study 2 was the evaluation of blood brain perfusion in two animal models of the SCZ-like phenotype. Study 3 was focused on the evaluation of cerebral blood perfusion in the well validated poly(I:C) model of SCZ in Wistar rats taking into account sex-dependent effects and the effect of aripiprazole treatment.

Název v anglickém jazyce

MRI findings induced by antipsychotic treatment and animal models of schizophrenia-like pathology

Popis výsledku anglicky

Schizophrenia (SCZ) is a debilitating mental illness resulting in multiple structural and functional brain changes. We used Arterial Spin Labelling MRI technique in all studies to evaluate cerebral blood perfusion in SCZ-related brain regions using Bruker BioSpec 94/30 scanner. Study 1 was focused on the effect of acute and chronic olanzapine exposure. The aim of Study 2 was the evaluation of blood brain perfusion in two animal models of the SCZ-like phenotype. Study 3 was focused on the evaluation of cerebral blood perfusion in the well validated poly(I:C) model of SCZ in Wistar rats taking into account sex-dependent effects and the effect of aripiprazole treatment.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30215 - Psychiatry

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů