Zinc Modified Nanotransporter of Anticancer Drugs for Targeted Therapy: Biophysical Analysis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F19%3A43878226" target="_blank" >RIV/62157124:16370/19:43878226 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.ingentaconnect.com/content/asp/jnn/2019/00000019/00000005/art00005;jsessionid=543npt3ohaft5.x-ic-live-02" target="_blank" >https://www.ingentaconnect.com/content/asp/jnn/2019/00000019/00000005/art00005;jsessionid=543npt3ohaft5.x-ic-live-02</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1166/jnn.2019.15870" target="_blank" >10.1166/jnn.2019.15870</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Zinc Modified Nanotransporter of Anticancer Drugs for Targeted Therapy: Biophysical Analysis

Popis výsledku v původním jazyce

Modern anticancer therapy aims to increase the effectiveness of tumor treatment. The aim of this work was to propose a new nanotransporter for targeted delivery of anthracycline antibiotics, which is characterized by its bioavailability, increased uptake of the drug from the bloodstream at the site of the tumor tissue as well as low toxicity to non-target tissue. Chitosan nanoparticles have attracted great attention in the field of drug delivery due to their stability, low toxicity and easy preparation. Deacetylated chitosan skeleton is composed of glucosamine units and has a high density of charged amino groups which allow strong electrostatic interactions with biomolecules, transition metals (Zn, Se) and peptides. We obtained an effective level of chitosan encapsulation, 20%. Electrochemical detection of the bounded Zn2+ ions into the chitosan structure showed a potential shift from -0.99 to -0.93 V. This result proved the formation of a chitosan-zinc complex. The ability of metallothione to quench the 2,2-diphenyl-1-picrylhydrazyl radical in the presence of 50 mu M doxorubicin was confirmed by the change of relative absorbance over the range from 50 to 60%.

Název v anglickém jazyce

Zinc Modified Nanotransporter of Anticancer Drugs for Targeted Therapy: Biophysical Analysis

Popis výsledku anglicky

Modern anticancer therapy aims to increase the effectiveness of tumor treatment. The aim of this work was to propose a new nanotransporter for targeted delivery of anthracycline antibiotics, which is characterized by its bioavailability, increased uptake of the drug from the bloodstream at the site of the tumor tissue as well as low toxicity to non-target tissue. Chitosan nanoparticles have attracted great attention in the field of drug delivery due to their stability, low toxicity and easy preparation. Deacetylated chitosan skeleton is composed of glucosamine units and has a high density of charged amino groups which allow strong electrostatic interactions with biomolecules, transition metals (Zn, Se) and peptides. We obtained an effective level of chitosan encapsulation, 20%. Electrochemical detection of the bounded Zn2+ ions into the chitosan structure showed a potential shift from -0.99 to -0.93 V. This result proved the formation of a chitosan-zinc complex. The ability of metallothione to quench the 2,2-diphenyl-1-picrylhydrazyl radical in the presence of 50 mu M doxorubicin was confirmed by the change of relative absorbance over the range from 50 to 60%.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

21001 - Nano-materials (production and properties)

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Nanoscience and Nanotechnology

ISSN

1533-4880

e-ISSN

—

Svazek periodika

19

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

2483-2488

Kód UT WoS článku

000458402700005

EID výsledku v databázi Scopus

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