Antibiotic resistance beyond the wall of the hospital: the environment and wildlife as reservoirs of bacteria resistant to critically important antibiotics

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16810%2F18%3A43876822" target="_blank" >RIV/62157124:16810/18:43876822 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Antibiotic resistance beyond the wall of the hospital: the environment and wildlife as reservoirs of bacteria resistant to critically important antibiotics

Popis výsledku v původním jazyce

The global dissemination of multidrug-resistant bacteria poses a major clinical challenge and serious threat to human health, leaving only a few or no therapeutic options for appropriate treatment of life-threatening diseases. Particular concern has been raised regarding the evidence of increasing incidence of resistant bacteria in wildlife and the environment. However, the reasons behind the presence and success of multidrug-resistant bacteria and their epidemiological plasmids in antibiotic-free environments remain uncovered. We provide detail genetic analysis of the isolates, particularly clinically important clonal lineages and plasmid groups disseminating emerging resistance mechanisms such as extended-spectrum beta-lactamases, carbapenemases and quinolone-resistance. To clarify the as-yet minimally explored complexity of potential transmission routes of such strains between different ecological niches, comparative genomics of the wide collection of isolates of diverse origin, including humans, animals and the environment, were performed. We identify plausible sources for the bacteria found in the environment and in wild bird populations, and document an alarming dissemination of emerging clones and epidemic plasmid groups that carry clinically important antibiotic resistance mechanisms. Our data reveal broad genetic commonalities among multidrug-resistant isolates from different source groups, strongly suggesting an exchange of genotypes (i.e., strains, resistance genes or plasmids) between isolates of diverse origin. We demonstrate the existence of environmental reservoirs and potential animal vectors for strains of human health importance such as pandemic Escherichia coli ST131. The data broadens our knowledge regarding the successful spread of particular multidrug-resistant E. coli clones between different ecological niches, including the environment and wastewaters. Our results highlights the significant role of migrating wild birds with distinctive dietary habits that live in environments highly influenced by anthropogenic activities in the dissemination of clinically important bacteria.

Název v anglickém jazyce

Antibiotic resistance beyond the wall of the hospital: the environment and wildlife as reservoirs of bacteria resistant to critically important antibiotics

Popis výsledku anglicky

The global dissemination of multidrug-resistant bacteria poses a major clinical challenge and serious threat to human health, leaving only a few or no therapeutic options for appropriate treatment of life-threatening diseases. Particular concern has been raised regarding the evidence of increasing incidence of resistant bacteria in wildlife and the environment. However, the reasons behind the presence and success of multidrug-resistant bacteria and their epidemiological plasmids in antibiotic-free environments remain uncovered. We provide detail genetic analysis of the isolates, particularly clinically important clonal lineages and plasmid groups disseminating emerging resistance mechanisms such as extended-spectrum beta-lactamases, carbapenemases and quinolone-resistance. To clarify the as-yet minimally explored complexity of potential transmission routes of such strains between different ecological niches, comparative genomics of the wide collection of isolates of diverse origin, including humans, animals and the environment, were performed. We identify plausible sources for the bacteria found in the environment and in wild bird populations, and document an alarming dissemination of emerging clones and epidemic plasmid groups that carry clinically important antibiotic resistance mechanisms. Our data reveal broad genetic commonalities among multidrug-resistant isolates from different source groups, strongly suggesting an exchange of genotypes (i.e., strains, resistance genes or plasmids) between isolates of diverse origin. We demonstrate the existence of environmental reservoirs and potential animal vectors for strains of human health importance such as pandemic Escherichia coli ST131. The data broadens our knowledge regarding the successful spread of particular multidrug-resistant E. coli clones between different ecological niches, including the environment and wastewaters. Our results highlights the significant role of migrating wild birds with distinctive dietary habits that live in environments highly influenced by anthropogenic activities in the dissemination of clinically important bacteria.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

40301 - Veterinary science

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů