Mechanism of Neonicotinoid Toxicity: Impact on Oxidative Stress and Metabolism

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18450%2F18%3A50014312" target="_blank" >RIV/62690094:18450/18:50014312 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1146/annurev-pharmtox-010617-052429" target="_blank" >http://dx.doi.org/10.1146/annurev-pharmtox-010617-052429</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1146/annurev-pharmtox-010617-052429" target="_blank" >10.1146/annurev-pharmtox-010617-052429</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mechanism of Neonicotinoid Toxicity: Impact on Oxidative Stress and Metabolism

Popis výsledku v původním jazyce

Thousands of tons of neonicotinoids are widely used around the world as broad-spectrum systemic insecticides and veterinary drugs. Researchers originally thought that neonicotinoids exhibited low mammalian toxicity. However, following their widespread use, it became increasingly evident that neonicotinoids could have various toxic effects on vertebrates and invertebrates. The primary focus of this review is to summarize the research progress associated with oxidative stress as a plausible mechanism for neonicotinoid-induced toxicity as well as neonicotinoid metabolism. This review summarizes the research conducted over the past decade into the production of reactive oxygen species, reactive nitrogen species, and oxidative stress as a result of neonicotinoid treatments, along with their correlation with the toxicity and metabolism of neonicotinoids. The metabolism of neonicotinoids and protection of various compounds against neonicotinoid-induced toxicity based on their antioxidative effects is also discussed. This review sheds new light on the critical roles of oxidative stress in neonicotinoid-induced toxicity to nontarget species.

Název v anglickém jazyce

Mechanism of Neonicotinoid Toxicity: Impact on Oxidative Stress and Metabolism

Popis výsledku anglicky

Thousands of tons of neonicotinoids are widely used around the world as broad-spectrum systemic insecticides and veterinary drugs. Researchers originally thought that neonicotinoids exhibited low mammalian toxicity. However, following their widespread use, it became increasingly evident that neonicotinoids could have various toxic effects on vertebrates and invertebrates. The primary focus of this review is to summarize the research progress associated with oxidative stress as a plausible mechanism for neonicotinoid-induced toxicity as well as neonicotinoid metabolism. This review summarizes the research conducted over the past decade into the production of reactive oxygen species, reactive nitrogen species, and oxidative stress as a result of neonicotinoid treatments, along with their correlation with the toxicity and metabolism of neonicotinoids. The metabolism of neonicotinoids and protection of various compounds against neonicotinoid-induced toxicity based on their antioxidative effects is also discussed. This review sheds new light on the critical roles of oxidative stress in neonicotinoid-induced toxicity to nontarget species.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Annual review of pharmacology and toxicology

ISSN

0362-1642

e-ISSN

—

Svazek periodika

58

Číslo periodika v rámci svazku

January

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

37

Strana od-do

471-507

Kód UT WoS článku

000424635500024

EID výsledku v databázi Scopus

2-s2.0-85040581167