Preparation, In Vitro Screening and Molecular Modelling of Monoquaternary Compounds Related to the Selective Acetylcholinesterase Inhibitor BW284c51
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F15%3A50003043" target="_blank" >RIV/62690094:18470/15:50003043 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/60162694:G44__/15:43875335 RIV/00179906:_____/15:10292633
Výsledek na webu
<a href="http://benthamscience.com/journal/abstracts.php?journalID=mc&articleID=121875" target="_blank" >http://benthamscience.com/journal/abstracts.php?journalID=mc&articleID=121875</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/1573406410666140428153110" target="_blank" >10.2174/1573406410666140428153110</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Preparation, In Vitro Screening and Molecular Modelling of Monoquaternary Compounds Related to the Selective Acetylcholinesterase Inhibitor BW284c51
Popis výsledku v původním jazyce
This paper describes preparation and in vitro evaluation of 19 compounds related to the selective experimental cholinesterase inhibitor BW284c51. The novel compounds were prepared as fragments of parent molecule BW284c51 and evaluated on the model of human recombinant acetylcholinesterase and human plasmatic butyrylcholinesterase. The IC50 values of the prepared compounds were compared to the parent molecule BW284c51. None of the compounds was superior to the parent drug, but two BW284c51 fragments showed promising hAChE inhibition in M scale and improved selectivity. These two fragments were further subjected to the molecular modelling study and their enzyme interactions were rationalized. The structure-activity relationship of the prepared series wasstated.
Název v anglickém jazyce
Preparation, In Vitro Screening and Molecular Modelling of Monoquaternary Compounds Related to the Selective Acetylcholinesterase Inhibitor BW284c51
Popis výsledku anglicky
This paper describes preparation and in vitro evaluation of 19 compounds related to the selective experimental cholinesterase inhibitor BW284c51. The novel compounds were prepared as fragments of parent molecule BW284c51 and evaluated on the model of human recombinant acetylcholinesterase and human plasmatic butyrylcholinesterase. The IC50 values of the prepared compounds were compared to the parent molecule BW284c51. None of the compounds was superior to the parent drug, but two BW284c51 fragments showed promising hAChE inhibition in M scale and improved selectivity. These two fragments were further subjected to the molecular modelling study and their enzyme interactions were rationalized. The structure-activity relationship of the prepared series wasstated.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FR - Farmakologie a lékárnická chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Medicinal chemistry
ISSN
1573-4064
e-ISSN
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Svazek periodika
11
Číslo periodika v rámci svazku
1
Stát vydavatele periodika
AE - Spojené arabské emiráty
Počet stran výsledku
9
Strana od-do
21-29
Kód UT WoS článku
000349330100004
EID výsledku v databázi Scopus
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