A Direct Interaction Between Mitochondrial Proteins and Amyloid-beta Peptide and its Significance for the Progression and Treatment of Alzheimer's Disease
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F15%3A50003442" target="_blank" >RIV/62690094:18470/15:50003442 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/60162694:G44__/15:43875349 RIV/00216208:11160/15:10294117 RIV/00179906:_____/15:10294117
Výsledek na webu
<a href="http://benthamscience.com/journal/abstracts.php?journalID=cmc&articleID=127660" target="_blank" >http://benthamscience.com/journal/abstracts.php?journalID=cmc&articleID=127660</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/0929867322666150114163051" target="_blank" >10.2174/0929867322666150114163051</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
A Direct Interaction Between Mitochondrial Proteins and Amyloid-beta Peptide and its Significance for the Progression and Treatment of Alzheimer's Disease
Popis výsledku v původním jazyce
The amyloid-beta peptide (A beta) has been associated with Alzheimer's disease (AD) for decades. The original amyloid cascade hypothesis declared that the insoluble extracellular plaques were responsible for A beta toxicity. Later, this hypothesis has been updated and soluble intracellular A beta forms and their effects within the cell have come into focus. Mitochondrial dysfunction plays an important role in the pathophysiology of AD. A beta was detected inside mitochondria and several mitochondrial proteins were found to interact directly with A beta. Such interactions can affect a protein's function and cause damage to the mitochondria and finally to the whole cell. This review summarizes the current knowledge of mitochondrial proteins directly interacting with A beta and discusses their significance for the development of therapeutics in the treatment of AD.
Název v anglickém jazyce
A Direct Interaction Between Mitochondrial Proteins and Amyloid-beta Peptide and its Significance for the Progression and Treatment of Alzheimer's Disease
Popis výsledku anglicky
The amyloid-beta peptide (A beta) has been associated with Alzheimer's disease (AD) for decades. The original amyloid cascade hypothesis declared that the insoluble extracellular plaques were responsible for A beta toxicity. Later, this hypothesis has been updated and soluble intracellular A beta forms and their effects within the cell have come into focus. Mitochondrial dysfunction plays an important role in the pathophysiology of AD. A beta was detected inside mitochondria and several mitochondrial proteins were found to interact directly with A beta. Such interactions can affect a protein's function and cause damage to the mitochondria and finally to the whole cell. This review summarizes the current knowledge of mitochondrial proteins directly interacting with A beta and discusses their significance for the development of therapeutics in the treatment of AD.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CE - Biochemie
OECD FORD obor
—
Návaznosti výsledku
Projekt
<a href="/cs/project/LD14009" target="_blank" >LD14009: Příprava sloučenin ovlivňujících mitochondriální enzymy jako potenciálních léčiv Alzheimerovy nemoci</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Current medicinal chemistry
ISSN
0929-8673
e-ISSN
—
Svazek periodika
22
Číslo periodika v rámci svazku
9
Stát vydavatele periodika
AE - Spojené arabské emiráty
Počet stran výsledku
30
Strana od-do
1056-1085
Kód UT WoS článku
000350477600002
EID výsledku v databázi Scopus
—