Free Radicals and Antioxidants in Human Disease
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F17%3A50016139" target="_blank" >RIV/62690094:18470/17:50016139 - isvavai.cz</a>
Výsledek na webu
<a href="https://www.springer.com/gp/book/9783319676234" target="_blank" >https://www.springer.com/gp/book/9783319676234</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-3-319-67625-8_12" target="_blank" >10.1007/978-3-319-67625-8_12</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Free Radicals and Antioxidants in Human Disease
Popis výsledku v původním jazyce
Free radicals are species containing one or more unpaired electrons. Unpaired or free electrons are responsible for enhanced reactivity of free radicals with various biomolecules. Most frequently occurring radicals in biological systems are reactive oxygen species (ROS) and reactive nitrogen species (RNS). ROS and RNS are generated by the tightly regulated enzymes, nicotinamide adenine dinucleotide phosphate oxidase isoforms and nitric oxide synthases. Overproduction of ROS and RNS results in oxidative and nitrosative stress, a state which is responsible for the damage to cell macromolecules including lipids, proteins and DNA. Oxidative stress has been implicated in the aetiology of various disease states of an organism. In this chapter, we discuss the biochemistry of free radicals and their impact on the development of various diseases. Organs of biological systems are the principal targets of oxidant species, which are implicated in atherosclerosis, diabetes, carcinogenesis and neurodegeneration. Attention is focused on oxidative stress-induced cardiovascular disease, type 2 diabetes, cancer and Alzheimer’s disease. The roles of redox active metal-catalysed formation of ROS and antioxidants in protection against oxidative damage is also discussed.
Název v anglickém jazyce
Free Radicals and Antioxidants in Human Disease
Popis výsledku anglicky
Free radicals are species containing one or more unpaired electrons. Unpaired or free electrons are responsible for enhanced reactivity of free radicals with various biomolecules. Most frequently occurring radicals in biological systems are reactive oxygen species (ROS) and reactive nitrogen species (RNS). ROS and RNS are generated by the tightly regulated enzymes, nicotinamide adenine dinucleotide phosphate oxidase isoforms and nitric oxide synthases. Overproduction of ROS and RNS results in oxidative and nitrosative stress, a state which is responsible for the damage to cell macromolecules including lipids, proteins and DNA. Oxidative stress has been implicated in the aetiology of various disease states of an organism. In this chapter, we discuss the biochemistry of free radicals and their impact on the development of various diseases. Organs of biological systems are the principal targets of oxidant species, which are implicated in atherosclerosis, diabetes, carcinogenesis and neurodegeneration. Attention is focused on oxidative stress-induced cardiovascular disease, type 2 diabetes, cancer and Alzheimer’s disease. The roles of redox active metal-catalysed formation of ROS and antioxidants in protection against oxidative damage is also discussed.
Klasifikace
Druh
C - Kapitola v odborné knize
CEP obor
—
OECD FORD obor
10608 - Biochemistry and molecular biology
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2017
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název knihy nebo sborníku
Nutritional Antioxidant Therapies: Treatments and Perspectives
ISBN
978-3-319-67623-4
Počet stran výsledku
23
Strana od-do
283-305
Počet stran knihy
553
Název nakladatele
Springer
Místo vydání
Cham
Kód UT WoS kapitoly
—