Acute Toxic Injuries of Rat's Visceral Tissues Induced by Different Oximes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F19%3A50016109" target="_blank" >RIV/62690094:18470/19:50016109 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.nature.com/articles/s41598-019-52768-4" target="_blank" >https://www.nature.com/articles/s41598-019-52768-4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41598-019-52768-4" target="_blank" >10.1038/s41598-019-52768-4</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Acute Toxic Injuries of Rat's Visceral Tissues Induced by Different Oximes

Popis výsledku v původním jazyce

Certain AChE reactivators, asoxime, obidoxime, K027, K048, and K075, when taken in overdoses and sometimes even when introduced within therapeutic ranges, may injure the different organs. As a continuation of previously published data, in this study, Wistar rats have sacrificed 24 hrs and 7 days after single im application of 0.1LD(50), 0.5LD(50) and 1.0LD(50) of each reactivator, and examinated tissue samples were obtained for pathohistological and semiquantitative analysis. A severity of tissue alteration, expressed as different tissue damage scores were evaluated. Morphological structure of examinated tissues treated with of 0.1LD(50) of all reactivators was comparable with the control group of rats. Moderate injuries were seen in visceral tissues treated with 0.5LD(50) of asoxime, obidoxime and K027. Acute damages were enlarged after treatment with 0.5LD(50) and 1.0LD(50) of all reactivators during the next 7 days. The most prominent changes were seen in rats treated with 1.0LD(50) of K048 and K075 (P &lt; 0.001 vs. control and asoxime-treated group). All reactivators given by a single, high, unitary dose regimen, have an adverse effect not only on the main visceral tissue, but on the whole rat as well, but the exact mechanism of cellular injury remains to be confirmed in further investigation.

Název v anglickém jazyce

Acute Toxic Injuries of Rat's Visceral Tissues Induced by Different Oximes

Popis výsledku anglicky

Certain AChE reactivators, asoxime, obidoxime, K027, K048, and K075, when taken in overdoses and sometimes even when introduced within therapeutic ranges, may injure the different organs. As a continuation of previously published data, in this study, Wistar rats have sacrificed 24 hrs and 7 days after single im application of 0.1LD(50), 0.5LD(50) and 1.0LD(50) of each reactivator, and examinated tissue samples were obtained for pathohistological and semiquantitative analysis. A severity of tissue alteration, expressed as different tissue damage scores were evaluated. Morphological structure of examinated tissues treated with of 0.1LD(50) of all reactivators was comparable with the control group of rats. Moderate injuries were seen in visceral tissues treated with 0.5LD(50) of asoxime, obidoxime and K027. Acute damages were enlarged after treatment with 0.5LD(50) and 1.0LD(50) of all reactivators during the next 7 days. The most prominent changes were seen in rats treated with 1.0LD(50) of K048 and K075 (P &lt; 0.001 vs. control and asoxime-treated group). All reactivators given by a single, high, unitary dose regimen, have an adverse effect not only on the main visceral tissue, but on the whole rat as well, but the exact mechanism of cellular injury remains to be confirmed in further investigation.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30108 - Toxicology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Scientific reports

ISSN

2045-2322

e-ISSN

—

Svazek periodika

9

Číslo periodika v rámci svazku

November

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

13

Strana od-do

"Article Number: 16425"

Kód UT WoS článku

000495611100017

EID výsledku v databázi Scopus

2-s2.0-85074864343