The hunt for radiation biomarkers: current situation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F20%3A50016194" target="_blank" >RIV/62690094:18470/20:50016194 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60162694:G44__/20:00555431

Výsledek na webu

<a href="https://www.tandfonline.com/doi/abs/10.1080/09553002.2020.1704909?journalCode=irab20" target="_blank" >https://www.tandfonline.com/doi/abs/10.1080/09553002.2020.1704909?journalCode=irab20</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/09553002.2020.1704909" target="_blank" >10.1080/09553002.2020.1704909</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The hunt for radiation biomarkers: current situation

Popis výsledku v původním jazyce

Purpose: The possibility of a large-scale acute radiation exposure necessitates the development of new methods that could provide a rapid assessment of the doses received by individuals using high-throughput technologies. There is also a great interest in developing new biomarkers of dose exposure, which could be used in large molecular epidemiological studies in order to correlate estimated doses received and health effects. The goal of this review was to summarize current literature focused on biological dosimetry, namely radiation-responsive biomarkers. Methods: The studies involved in this review were thoroughly selected according to the determined criteria and PRISMA guidelines. Results: We described briefly recent advances in radiation genomics and metabolomics, giving particular emphasis to proteomic analysis. The majority of studies were performed on animal models (rats, mice, and non-human primates). They have provided much beneficial information, but the most relevant tests have been done on human (oncological) patients. By inspecting the radiaiton biodosimetry literate of the last 10years, we identified a panel of candidate markers for each –omic approach involved. Conslusions: We reviewed different methodological approaches and various biological materials, which can be exploited for dose-effect prediction. The protein biomarkers from human plasma are ideal for this specific purpose. From a plethora of candidate markers, FDXR is a very promising transcriptomic candidate, and importantly this biomarker was also confirmed by some studies at protein level in humans.

Název v anglickém jazyce

The hunt for radiation biomarkers: current situation

Popis výsledku anglicky

Purpose: The possibility of a large-scale acute radiation exposure necessitates the development of new methods that could provide a rapid assessment of the doses received by individuals using high-throughput technologies. There is also a great interest in developing new biomarkers of dose exposure, which could be used in large molecular epidemiological studies in order to correlate estimated doses received and health effects. The goal of this review was to summarize current literature focused on biological dosimetry, namely radiation-responsive biomarkers. Methods: The studies involved in this review were thoroughly selected according to the determined criteria and PRISMA guidelines. Results: We described briefly recent advances in radiation genomics and metabolomics, giving particular emphasis to proteomic analysis. The majority of studies were performed on animal models (rats, mice, and non-human primates). They have provided much beneficial information, but the most relevant tests have been done on human (oncological) patients. By inspecting the radiaiton biodosimetry literate of the last 10years, we identified a panel of candidate markers for each –omic approach involved. Conslusions: We reviewed different methodological approaches and various biological materials, which can be exploited for dose-effect prediction. The protein biomarkers from human plasma are ideal for this specific purpose. From a plethora of candidate markers, FDXR is a very promising transcriptomic candidate, and importantly this biomarker was also confirmed by some studies at protein level in humans.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10609 - Biochemical research methods

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International journal of radiation biology

ISSN

0955-3002

e-ISSN

—

Svazek periodika

96

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

13

Strana od-do

370-382

Kód UT WoS článku

000516972500009

EID výsledku v databázi Scopus

2-s2.0-85077843182