Wide-Antimicrobial Spectrum of Picolinium Salts

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F20%3A50016826" target="_blank" >RIV/62690094:18470/20:50016826 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378050:_____/20:00525589 RIV/60162694:G44__/20:00555750 RIV/00179906:_____/20:10412307

Výsledek na webu

<a href="https://www.mdpi.com/1420-3049/25/9/2254" target="_blank" >https://www.mdpi.com/1420-3049/25/9/2254</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/molecules25092254" target="_blank" >10.3390/molecules25092254</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Wide-Antimicrobial Spectrum of Picolinium Salts

Popis výsledku v původním jazyce

Nosocomial infections, which greatly increase morbidity among hospitalized patients, together with growing antibiotic resistance still encourage many researchers to search for novel antimicrobial compounds. Picolinium salts with different lengths of alkyl chains (C-12, C-14, C-16) were prepared by Menshutkin-like reaction and evaluated with respect to their biological activity, i.e., lipophilicity and critical micellar concentration. Picolinium salts with C-14 and C-16 side chains achieved similar or even better results when in terms of antimicrobial efficacy than benzalkoniums; notably, their fungicidal efficiency was substantially more potent. The position of the methyl substituent on the aromatic ring does not seem to affect antimicrobial activity, in contrast to the effect of length of the N-alkyl chain. Concurrently, picolinium salts exhibited satisfactory low cytotoxicity against mammalian cells, i.e., lower than that of benzalkonium compounds, which are considered as safe.

Název v anglickém jazyce

Wide-Antimicrobial Spectrum of Picolinium Salts

Popis výsledku anglicky

Nosocomial infections, which greatly increase morbidity among hospitalized patients, together with growing antibiotic resistance still encourage many researchers to search for novel antimicrobial compounds. Picolinium salts with different lengths of alkyl chains (C-12, C-14, C-16) were prepared by Menshutkin-like reaction and evaluated with respect to their biological activity, i.e., lipophilicity and critical micellar concentration. Picolinium salts with C-14 and C-16 side chains achieved similar or even better results when in terms of antimicrobial efficacy than benzalkoniums; notably, their fungicidal efficiency was substantially more potent. The position of the methyl substituent on the aromatic ring does not seem to affect antimicrobial activity, in contrast to the effect of length of the N-alkyl chain. Concurrently, picolinium salts exhibited satisfactory low cytotoxicity against mammalian cells, i.e., lower than that of benzalkonium compounds, which are considered as safe.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

<a href="/cs/project/NV19-09-00198" target="_blank" >NV19-09-00198: Vývoj nových látek na bázi kvartérních amoniových sloučenin proti mikrobiálním biofilmům ústní dutiny</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

MOLECULES

ISSN

1420-3049

e-ISSN

—

Svazek periodika

25

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

16

Strana od-do

"Article Number: 2254"

Kód UT WoS článku

000535695900250

EID výsledku v databázi Scopus

2-s2.0-85084415087