Pyridostigmine bromide and its relation to Gulf War illness

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F20%3A50016831" target="_blank" >RIV/62690094:18470/20:50016831 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60162694:G44__/20:00555792 RIV/00216208:11150/20:10418100 RIV/00179906:_____/20:10418100

Výsledek na webu

<a href="https://www.tandfonline.com/doi/full/10.1080/15569543.2018.1480496" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/15569543.2018.1480496</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/15569543.2018.1480496" target="_blank" >10.1080/15569543.2018.1480496</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Pyridostigmine bromide and its relation to Gulf War illness

Popis výsledku v původním jazyce

Pyridostigmine bromide acts as a reversible cholinesterase inhibitor that is used at relatively high doses in treatment of Myasthenia gravis and in low dose regimens as prophylaxis against nerve agents poisoning during the Gulf War. The manifestation of late nonspecific symptoms commonly called Gulf War illness has led to the discussion about the role of pyridostigmine bromide in the pathogenesis of this illness. In our study, we described plasma absorption profile of pyridostigmine bromide after p.o. administration in rats; subsequently, changes in blood biochemical and oxidative stress markers were measured. Pyridostigmine bromide was applied p.o. at the dose of 5.82 mg/kg b.w. according to the previously published recommendations. The absorption of pyridostigmine was relatively fast; the C-max in plasma was 110.20 +/- 15.12 ng/ml at T-max of 197.12 +/- 17.14 min. The bioavailability expressed as AUC(total) was 44,348 +/- 7608 min ng/ml. The prolongation of pyridostigmine in circulation is in agreement with relatively long half-life that was 179.00 +/- 28.54 min. Several blood biochemical markers were altered, including glucose, creatinine, creatine kinase, alanine aminotransferase, aspartate aminotransferase, interleukin-6, triglycerides, and cholesterol. However, the changes could be considered as mild. Thiobarbituric acid reactive substances and ferric reducing ability of plasma indicate suppression of basal metabolism. The results of blood biochemical and oxidative stress markers imply that long-term use might possibly change the basal metabolism and cause cellular damage with inflammatory changes.

Název v anglickém jazyce

Pyridostigmine bromide and its relation to Gulf War illness

Popis výsledku anglicky

Pyridostigmine bromide acts as a reversible cholinesterase inhibitor that is used at relatively high doses in treatment of Myasthenia gravis and in low dose regimens as prophylaxis against nerve agents poisoning during the Gulf War. The manifestation of late nonspecific symptoms commonly called Gulf War illness has led to the discussion about the role of pyridostigmine bromide in the pathogenesis of this illness. In our study, we described plasma absorption profile of pyridostigmine bromide after p.o. administration in rats; subsequently, changes in blood biochemical and oxidative stress markers were measured. Pyridostigmine bromide was applied p.o. at the dose of 5.82 mg/kg b.w. according to the previously published recommendations. The absorption of pyridostigmine was relatively fast; the C-max in plasma was 110.20 +/- 15.12 ng/ml at T-max of 197.12 +/- 17.14 min. The bioavailability expressed as AUC(total) was 44,348 +/- 7608 min ng/ml. The prolongation of pyridostigmine in circulation is in agreement with relatively long half-life that was 179.00 +/- 28.54 min. Several blood biochemical markers were altered, including glucose, creatinine, creatine kinase, alanine aminotransferase, aspartate aminotransferase, interleukin-6, triglycerides, and cholesterol. However, the changes could be considered as mild. Thiobarbituric acid reactive substances and ferric reducing ability of plasma indicate suppression of basal metabolism. The results of blood biochemical and oxidative stress markers imply that long-term use might possibly change the basal metabolism and cause cellular damage with inflammatory changes.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30108 - Toxicology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Toxin Reviews

ISSN

1556-9543

e-ISSN

—

Svazek periodika

39

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

138-146

Kód UT WoS článku

000532601200005

EID výsledku v databázi Scopus

2-s2.0-85049578171