The role of the immune system and the biomarker CD3+CD4+CD45RA-CD62L-in the pathophysiology of migraine

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F20%3A50017013" target="_blank" >RIV/62690094:18470/20:50017013 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/20:10418374 RIV/00179906:_____/20:10418374

Výsledek na webu

<a href="https://www.nature.com/articles/s41598-020-69285-4" target="_blank" >https://www.nature.com/articles/s41598-020-69285-4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41598-020-69285-4" target="_blank" >10.1038/s41598-020-69285-4</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The role of the immune system and the biomarker CD3+CD4+CD45RA-CD62L-in the pathophysiology of migraine

Popis výsledku v původním jazyce

The role of the immune system as an integral component of the inflammatory response in the pathophysiology of migraine remains unclear. The aim of this study was to evaluate the differences in immune system parameters (acquired immunity parameters) in patients with episodic migraine (EM) and in healthy controls. In EM patients, we aimed to determine whether the changes found in peripheral blood parameters were related to migraine severity according to the standardised MIDAS and HIT-6 tests. Forty-nine patients with EM and 50 healthy controls were included in this study. The authors compared different lymphocyte parameters obtained by multicolor flow cytometry in the EM and control groups by performing statistical tests. The relationship between the changes in peripheral blood parameters and migraine severity in EM patients was investigated using correlation and regression analysis. EM patients showed higher values than healthy controls, especially in nine parameters: relative count of lymphocytes, relative and absolute counts of CD3 T cells, relative and absolute counts of CD8 suppressor cytotoxic T cells, relative and absolute counts of CD4+T-EMRA (terminally differentiated helper T lymphocytes), absolute count of CD8 naive T cells, and absolute count of CD19 switched memory B cells. Among the lymphocyte parameters, CD4+T-EM (effector memory helper T lymphocytes) and CD8+T-EMRA (terminally differentiated cytotoxic T lymphocytes) were statistically significantly associated with HIT-6. Patients with a CD4+T-EM value below 15 had a high probability (90%) that the HIT-6 value would be higher than 60. The results of this study show that EM patients have changes in immune system parameters measured in the peripheral blood. Changes in the abundance of CD4+T-EM could be used as a biomarker for disease severity.

Název v anglickém jazyce

The role of the immune system and the biomarker CD3+CD4+CD45RA-CD62L-in the pathophysiology of migraine

Popis výsledku anglicky

The role of the immune system as an integral component of the inflammatory response in the pathophysiology of migraine remains unclear. The aim of this study was to evaluate the differences in immune system parameters (acquired immunity parameters) in patients with episodic migraine (EM) and in healthy controls. In EM patients, we aimed to determine whether the changes found in peripheral blood parameters were related to migraine severity according to the standardised MIDAS and HIT-6 tests. Forty-nine patients with EM and 50 healthy controls were included in this study. The authors compared different lymphocyte parameters obtained by multicolor flow cytometry in the EM and control groups by performing statistical tests. The relationship between the changes in peripheral blood parameters and migraine severity in EM patients was investigated using correlation and regression analysis. EM patients showed higher values than healthy controls, especially in nine parameters: relative count of lymphocytes, relative and absolute counts of CD3 T cells, relative and absolute counts of CD8 suppressor cytotoxic T cells, relative and absolute counts of CD4+T-EMRA (terminally differentiated helper T lymphocytes), absolute count of CD8 naive T cells, and absolute count of CD19 switched memory B cells. Among the lymphocyte parameters, CD4+T-EM (effector memory helper T lymphocytes) and CD8+T-EMRA (terminally differentiated cytotoxic T lymphocytes) were statistically significantly associated with HIT-6. Patients with a CD4+T-EM value below 15 had a high probability (90%) that the HIT-6 value would be higher than 60. The results of this study show that EM patients have changes in immune system parameters measured in the peripheral blood. Changes in the abundance of CD4+T-EM could be used as a biomarker for disease severity.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Scientific reports

ISSN

2045-2322

e-ISSN

—

Svazek periodika

10

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

"Article Number: 12277"

Kód UT WoS článku

000556698500029

EID výsledku v databázi Scopus

2-s2.0-85088390929