Current Anti-Inflammatory Therapies and the Potential of Secretory Phospholipase A(2) Inhibitors in the Design of New Anti-Inflammatory Drugs: A Review of 2012-2018

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F20%3A50017122" target="_blank" >RIV/62690094:18470/20:50017122 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.ingentaconnect.com/content/ben/cmc/2020/00000027/00000003/art00010" target="_blank" >https://www.ingentaconnect.com/content/ben/cmc/2020/00000027/00000003/art00010</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/0929867326666190201120646" target="_blank" >10.2174/0929867326666190201120646</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Current Anti-Inflammatory Therapies and the Potential of Secretory Phospholipase A(2) Inhibitors in the Design of New Anti-Inflammatory Drugs: A Review of 2012-2018

Popis výsledku v původním jazyce

The inflammatory process is a natural self-defense response of the organism to damage agents and its action mechanism involves a series of complex reactions. However, in some cases, this process can become chronic, causing much harm to the body. Therefore, over the years, many anti-inflammatory drugs have been developed aiming to decrease the concentrations of inflammatory mediators in the organism, which is a way of controlling these abnormal chain reactions. The main target of conventional anti-inflammatory drugs is the cyclooxygenase (COX) enzyme, but its use implies several side effects. Thus, based on these limitations, many studies have been performed, aiming to create new drugs, with new action mechanisms. In this sense, the phospholipase A(2) (PLA(2)) enzymes stand out. Among all the existing isoforms, secretory PLA(2) is the major target for inhibitor development, since many studies have proven that this enzyme participates in various inflammatory conditions, such as cancer, Alzheimer and arthritis. Finally, for the purpose of developing anti-inflammatory drugs that are sPLA(2) inhibitors, many molecules have been designed. Accordingly, this work presents an overview of inflammatory processes and mediators, the current available anti-inflammatory drugs, and it briefly covers the PLA(2) enzymes, as well as the diverse structural array of the newest sPLA(2) inhibitors as a possible target for the production of new anti-inflammatory drugs.

Název v anglickém jazyce

Current Anti-Inflammatory Therapies and the Potential of Secretory Phospholipase A(2) Inhibitors in the Design of New Anti-Inflammatory Drugs: A Review of 2012-2018

Popis výsledku anglicky

The inflammatory process is a natural self-defense response of the organism to damage agents and its action mechanism involves a series of complex reactions. However, in some cases, this process can become chronic, causing much harm to the body. Therefore, over the years, many anti-inflammatory drugs have been developed aiming to decrease the concentrations of inflammatory mediators in the organism, which is a way of controlling these abnormal chain reactions. The main target of conventional anti-inflammatory drugs is the cyclooxygenase (COX) enzyme, but its use implies several side effects. Thus, based on these limitations, many studies have been performed, aiming to create new drugs, with new action mechanisms. In this sense, the phospholipase A(2) (PLA(2)) enzymes stand out. Among all the existing isoforms, secretory PLA(2) is the major target for inhibitor development, since many studies have proven that this enzyme participates in various inflammatory conditions, such as cancer, Alzheimer and arthritis. Finally, for the purpose of developing anti-inflammatory drugs that are sPLA(2) inhibitors, many molecules have been designed. Accordingly, this work presents an overview of inflammatory processes and mediators, the current available anti-inflammatory drugs, and it briefly covers the PLA(2) enzymes, as well as the diverse structural array of the newest sPLA(2) inhibitors as a possible target for the production of new anti-inflammatory drugs.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current medicinal chemistry

ISSN

0929-8673

e-ISSN

—

Svazek periodika

27

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

AE - Spojené arabské emiráty

Počet stran výsledku

21

Strana od-do

477-497

Kód UT WoS článku

000514833000009

EID výsledku v databázi Scopus

2-s2.0-85079557383