Novel Cholinesterase Reactivators

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F20%3A50017538" target="_blank" >RIV/62690094:18470/20:50017538 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/book/9780128190906/handbook-of-toxicology-of-chemical-warfare-agents" target="_blank" >https://www.sciencedirect.com/book/9780128190906/handbook-of-toxicology-of-chemical-warfare-agents</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/B978-0-12-819090-6.00069-6" target="_blank" >10.1016/B978-0-12-819090-6.00069-6</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Novel Cholinesterase Reactivators

Popis výsledku v původním jazyce

The continuous threat of organophosphorus (OP) nerve agent misuse supports the development of antidotes with enhanced potency. In this chapter, we focus on antidotal therapy with cholinesterase reactivators. Although this group of compounds has been known for more than a halfcentury, there is no single compound that might counteract every nerve agent’s lethal effects. This chapter describes in detail the design and synthesis of the cholinesterase reactivators that have been developed within the last decade. Within the design of novel molecules, special emphasis is placed on the structural requirements (structure-activity relationship) of these compounds. Finally, several new trends in the development of new reactivators are discussed.

Název v anglickém jazyce

Novel Cholinesterase Reactivators

Popis výsledku anglicky

The continuous threat of organophosphorus (OP) nerve agent misuse supports the development of antidotes with enhanced potency. In this chapter, we focus on antidotal therapy with cholinesterase reactivators. Although this group of compounds has been known for more than a halfcentury, there is no single compound that might counteract every nerve agent’s lethal effects. This chapter describes in detail the design and synthesis of the cholinesterase reactivators that have been developed within the last decade. Within the design of novel molecules, special emphasis is placed on the structural requirements (structure-activity relationship) of these compounds. Finally, several new trends in the development of new reactivators are discussed.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

30107 - Medicinal chemistry

Projekt

<a href="/cs/project/GA19-13628S" target="_blank" >GA19-13628S: Enkapsulace reaktivátorů cholinesteras pomocí apoferitinu pro zvýšení biodostupnosti v centrálním nervovém systému</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Handbook of Toxicology of Chemical Warfare Agents

ISBN

978-0-12-819090-6

Počet stran výsledku

17

Strana od-do

1161-1177

Počet stran knihy

1318

Název nakladatele

Elsevier

Místo vydání

Amsterdam

Kód UT WoS kapitoly

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