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Biomarkers of deoxynivalenol (DON) and its modified form DON-3-glucoside (DON-3G) in humans

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F21%3A50017903" target="_blank" >RIV/62690094:18470/21:50017903 - isvavai.cz</a>

  • Výsledek na webu

    <a href="https://www.sciencedirect.com/science/article/pii/S0924224421001448?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0924224421001448?via%3Dihub</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.tifs.2021.02.038" target="_blank" >10.1016/j.tifs.2021.02.038</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Biomarkers of deoxynivalenol (DON) and its modified form DON-3-glucoside (DON-3G) in humans

  • Popis výsledku v původním jazyce

    Background: To date, considerable research has been devoted to biomarkers of deoxynivalenol (DON) and its modified form DON-3-glucoside (DON-3G) in humans. Since these both cause toxic effects in humans, identifying the biomarkers of these toxins is crucial for human health. Scope and approach: In the present review, we systematically assess the profiles of human DON biomarkers in different regions, ages, sexes, and dietary habits; the specific features of DON biomarkers in pregnant women are discussed separately. We highlight recent advances in our knowledge of human DON-3G biomarkers. Key findings and conclusions: Free DON and DON-glucuronide (DON-GlcA) are the major biomarkers of DON in human urine, whereas DON-3-sulphate and the deepoxy product DOM-1 are the secondary biomarkers. The amount of DON exposure in children and adolescents is higher than that in adults, whereas the elderly show the lowest levels, suggesting that young people, including children, face greater health risks from this toxin. DON can cross the placental barrier from mothers and may inhibit foetal growth and immune function. The vegetarian population shows a higher risk of exposure to DON and DON-3G due to their greater consumption of vegetables and cereals. Animal studies show that females excrete DON and its principal metabolites, including DON-3-GlcA, in their urine more rapidly than males. DON-15-GlcA is the most prominent urinary biomarker of DON-3G. This review should help to further understanding the specific profiles of human DON and DON-3G biomarkers. © 2021 Elsevier Ltd

  • Název v anglickém jazyce

    Biomarkers of deoxynivalenol (DON) and its modified form DON-3-glucoside (DON-3G) in humans

  • Popis výsledku anglicky

    Background: To date, considerable research has been devoted to biomarkers of deoxynivalenol (DON) and its modified form DON-3-glucoside (DON-3G) in humans. Since these both cause toxic effects in humans, identifying the biomarkers of these toxins is crucial for human health. Scope and approach: In the present review, we systematically assess the profiles of human DON biomarkers in different regions, ages, sexes, and dietary habits; the specific features of DON biomarkers in pregnant women are discussed separately. We highlight recent advances in our knowledge of human DON-3G biomarkers. Key findings and conclusions: Free DON and DON-glucuronide (DON-GlcA) are the major biomarkers of DON in human urine, whereas DON-3-sulphate and the deepoxy product DOM-1 are the secondary biomarkers. The amount of DON exposure in children and adolescents is higher than that in adults, whereas the elderly show the lowest levels, suggesting that young people, including children, face greater health risks from this toxin. DON can cross the placental barrier from mothers and may inhibit foetal growth and immune function. The vegetarian population shows a higher risk of exposure to DON and DON-3G due to their greater consumption of vegetables and cereals. Animal studies show that females excrete DON and its principal metabolites, including DON-3-GlcA, in their urine more rapidly than males. DON-15-GlcA is the most prominent urinary biomarker of DON-3G. This review should help to further understanding the specific profiles of human DON and DON-3G biomarkers. © 2021 Elsevier Ltd

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    21101 - Food and beverages

Návaznosti výsledku

  • Projekt

  • Návaznosti

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Ostatní

  • Rok uplatnění

    2021

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Trends in Food Science and Technology

  • ISSN

    0924-2244

  • e-ISSN

  • Svazek periodika

    110

  • Číslo periodika v rámci svazku

    April

  • Stát vydavatele periodika

    GB - Spojené království Velké Británie a Severního Irska

  • Počet stran výsledku

    8

  • Strana od-do

    551-558

  • Kód UT WoS článku

    000632854800007

  • EID výsledku v databázi Scopus

    2-s2.0-85101374632